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Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic
Pathogens, 12 (2023), 5; 677. https://doi.org/10.3390/pathogens12050677
Bedenić, Branka; Luxner, Josefa; Car, Haris; Sardelić, Sanda; Bogdan, Maja; Varda-Brkić, Dijana; Šuto, Sandra; Grisold, Andrea; Beader, Nataša; Zarfel, Gernot

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Bedenić, B., Luxner, J., Car, H., Sardelić, S., Bogdan, M., Varda Brkić, D. ... Zarfel, G. (2023). Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic. Pathogens, 12. (5). doi: 10.3390/pathogens12050677

Bedenić, Branka, et al. "Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic." Pathogens, vol. 12, br. 5, 2023. https://doi.org/10.3390/pathogens12050677

Bedenić, Branka, Josefa Luxner, Haris Car, Sanda Sardelić, Maja Bogdan, Dijana Varda Brkić, Sandra Šuto, Andrea Grisold, Nataša Beader i Gernot Zarfel. "Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic." Pathogens 12, br. 5 (2023). https://doi.org/10.3390/pathogens12050677

Bedenić, B., et al. (2023) 'Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic', Pathogens, 12(5). doi: 10.3390/pathogens12050677

Bedenić B, Luxner J, Car H, Sardelić S, Bogdan M, Varda Brkić D, i sur.. Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic. Pathogens [Internet]. 03.05.2023. [pristupljeno 17.03.2025.];12(5). doi: 10.3390/pathogens12050677

B. Bedenić, et al., "Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic", Pathogens, vol. 12, br. 5, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:977021. [Citirano: 17.03.2025.]

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Podaci o radu
Naslov (engleski)Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic
AutorBranka Bedenić
AutorJosefa Luxner
AutorHaris Car
AutorSanda Sardelić
AutorMaja Bogdan
AutorDijana Varda-Brkić
AutorSandra Šuto
AutorAndrea Grisold
AutorNataša Beader
AutorGernot Zarfel
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Resistance to carbapenems in Enterobacterales has become a matter of the highest concern in the last decade. Recently, Enterobacterales harboring multiple carbapenemases were detected in three hospital centers in Croatia and in the outpatient setting, posing a serious therapeutic challenge for clinicians. In this study, we analyzed eight Klebsiella pneumoniae and two Enterobacter cloacae complex isolates with multiple carbapenemases, with regard to antibiotic susceptibility, β-lactamase... Više production and plasmid content. The isolates demonstrated uniform resistance to amoxicillin/clavulanate, piperacillin/tazobactam, cefuroxime, ceftazidime, cefotaxime, ceftriaxone and ertapenem. Among novel β-lactam/inhibitor combinations, ceftazidime/avibactam exhibited moderate activity, with 50% of isolates susceptible. All isolates demonstrated resistance to imipenem/cilastatin/relebactam, and all but one to ceftolozane/tazobactam. Four isolates exhibited a multidrug-resistant phenotype (MDR), whereas six were allocated to an extensively drug-resistant phenotype (XDR). OKNV detected three combinations of carbapenemases: OXA-48+NDM (five isolates), OXA-48+VIM (three isolates) and OXA-48+KPC (two isolates). Inter-array testing identified a wide variety of resistance genes for β-lactam antibiotics: blaCTX-M-15, blaTEM, blaSHV, blaOXA-1, blaOXA-2, blaOXA-9, aminoglycosides: aac6, aad, rmt, arm and aph, fluoroquinolones: qnrA, qnrB and qnrS, sulphonamides: sul1 and sul2 and trimethoprim: dfrA5, dfrA7, dfrA14, dfrA17 and dfrA19. mcr genes were reported for the first time in Croatia. This study demonstrated the ability of K. pneumoniae and E. cloacae to acquire various resistance determinants under the selection pressure of antibiotics widely used during the COVID-19 pandemic. The novel inter-array method showed good correlation with OKNV and PCR, although some discrepancies were found. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 12, br. 5, 677
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12050677
URN:NBNurn:nbn:hr:105:977021
Datum objave publikacije2023-05-03
URL dokumentahttps://www.mdpi.com/2076-0817/12/5/677
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-10-13 10:22:58
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