prikaz prve stranice dokumenta Proteomic exploration of potential blood biomarkers in haemophilic arthropathy
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Proteomic exploration of potential blood biomarkers in haemophilic arthropathy
Health Science Reports, 7 (2024), 9; e70046. https://doi.org/10.1002/hsr2.70046
Kalebota, Nataša; Novak, Ruđer; Hrkač, Stela; Perić, Porin; Salai, Grgur; Močibob, Marko; Pranjić, Marija; Zdráhal, Zbyněk; Pustka, Václav; Laktašić Žerjavić, Nadica; Milošević, Milan; Vodanović, Marijo; Šalek, Silva Zupančić; Grgurević, Lovorka

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Kalebota, N., Novak, R., Hrkač, S., Perić, P., Salai, G., Močibob, M. ... Grgurević, L. (2024). Proteomic exploration of potential blood biomarkers in haemophilic arthropathy. Health Science Reports, 7. (9). doi: 10.1002/hsr2.70046

Kalebota, Nataša, et al. "Proteomic exploration of potential blood biomarkers in haemophilic arthropathy." Health Science Reports, vol. 7, br. 9, 2024. https://doi.org/10.1002/hsr2.70046

Kalebota, Nataša, Ruđer Novak, Stela Hrkač, Porin Perić, Grgur Salai, Marko Močibob, Marija Pranjić, et al. "Proteomic exploration of potential blood biomarkers in haemophilic arthropathy." Health Science Reports 7, br. 9 (2024). https://doi.org/10.1002/hsr2.70046

Kalebota, N., et al. (2024) 'Proteomic exploration of potential blood biomarkers in haemophilic arthropathy', Health Science Reports, 7(9). doi: 10.1002/hsr2.70046

Kalebota N, Novak R, Hrkač S, Perić P, Salai G, Močibob M, i sur.. Proteomic exploration of potential blood biomarkers in haemophilic arthropathy. Health Science Reports [Internet]. 25.09.2024. [pristupljeno 20.03.2025.];7(9). doi: 10.1002/hsr2.70046

N. Kalebota, et al., "Proteomic exploration of potential blood biomarkers in haemophilic arthropathy", Health Science Reports, vol. 7, br. 9, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:964902. [Citirano: 20.03.2025.]

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Naslov (engleski)Proteomic exploration of potential blood biomarkers in haemophilic arthropathy
AutorNataša Kalebota
AutorRuđer Novak
AutorStela Hrkač
AutorPorin Perić
AutorGrgur Salai
AutorMarko Močibob
AutorMarija Pranjić
AutorZbyněk Zdráhal
AutorVáclav Pustka
AutorNadica Laktašić Žerjavić
AutorMilan Milošević
AutorMarijo Vodanović
AutorSilva Zupančić Šalek
AutorLovorka Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIKALNU MEDICINU I OPĆU REHABILITACIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Fizikalna medicina i rehabilitacija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Zdravstvena ekologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Background and aims: The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA.Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their potential as HA biomarkers. Methods: Our cross-sectional observational study encompassed 30 HA patients and 15 healthy subjects. Plasma samples were pooled... Više into three groups of 15 samples from those with severe haemophilic arthropathy (sHA), mild haemophilic arthropathy (mHA) and healthy controls. Proteomic analysis was performed using liquid chromatography-mass spectrometry. The severity of HA was assessed using the World Federation of Haemophilia Physical Examination Score and ultrasonography following the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) guidelines. Results: A total of 788 proteins were identified, with 97% of the uniquely identified proteins being expressed in all analysed groups. We identified several up and downregulated proteins across the groups that were mainly related to inflammatory and immunity-modulating processes, as well as joint degeneration. We highlighted ten proteins relevant for the development of HA: cathepsin G, endoplasmic reticulum aminopeptidase 2, S100-A9, insulin-like growth factor I, apolipoprotein (a), osteopontin, pregnancy zone protein, cartilage oligomeric matrix protein, CD44, and cadherin-related family member 2. Conclusion: Our analysis identified several proteins that shed further light on the distinctive pathogenesis of HA and could serve for biomarker research. However, these results need to be validated on a larger patient group. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaHealth Science Reports
Brojčani podacivol. 7, br. 9, e70046
p-ISSN2398-8835
e-ISSN2398-8835
DOIhttps://doi.org/10.1002/hsr2.70046
URN:NBNurn:nbn:hr:105:964902
Datum objave publikacije2024-09-25
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/hsr2.70046
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2025-03-20 08:31:25
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