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The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus
Frontiers in Neuroanatomy, 15 (2021); 749390. https://doi.org/10.3389/fnana.2021.749390
Bokulić, Ema; Medenica, Tila; Knezović, Vinka; Štajduhar, Andrija; Almahariq, Fadi; Baković, Marija; Judaš, Miloš; Sedmak, Goran

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Bokulić, E., Medenica, T., Knezović, V., Štajduhar, A., Almahariq, F., Baković, M. ... Sedmak, G. (2021). The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus. Frontiers in Neuroanatomy, 15.. doi: 10.3389/fnana.2021.749390

Bokulić, Ema, et al. "The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus." Frontiers in Neuroanatomy, vol. 15, 2021. https://doi.org/10.3389/fnana.2021.749390

Bokulić, Ema, Tila Medenica, Vinka Knezović, Andrija Štajduhar, Fadi Almahariq, Marija Baković, Miloš Judaš i Goran Sedmak. "The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus." Frontiers in Neuroanatomy 15 (2021). https://doi.org/10.3389/fnana.2021.749390

Bokulić, E., et al. (2021) 'The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus', Frontiers in Neuroanatomy, 15. doi: 10.3389/fnana.2021.749390

Bokulić E, Medenica T, Knezović V, Štajduhar A, Almahariq F, Baković M, i sur.. The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus. Frontiers in Neuroanatomy [Internet]. 14.12.2021. [pristupljeno 20.02.2025.];15. doi: 10.3389/fnana.2021.749390

E. Bokulić, et al., "The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus", Frontiers in Neuroanatomy, vol. 15, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:939063. [Citirano: 20.02.2025.]

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Naslov (engleski)The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus
AutorEma Bokulić
AutorTila Medenica
AutorVinka Knezović
AutorAndrija Štajduhar
AutorFadi Almahariq
AutorMarija Baković
AutorMiloš Judaš
AutorGoran Sedmak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU STATISTIKU, EPIDEMIOLOGIJU I MEDICINSKU INFORMATIKU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA SUDSKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sudska medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Epidemiologija
Sažetak (engleski)
The subthalamic nucleus (STN) is a small, ovoid structure, and an important site of deep brain stimulation (DBS) for the treatment of Parkinson's disease. Although the STN is a clinically important structure, there are many unresolved issues with regard to it. These issues are especially related to the anatomical subdivision, neuronal phenotype, neuronal composition, and spatial distribution. In this study, we have examined the expression pattern of 8 neuronal markers [nNOS, NeuN, parvalbumin... Više (PV), calbindin (CB), calretinin (CR), FOXP2, NKX2.1, and PAX6] in the adult human STN. All of the examined markers, except CB, were present in the STN. To determine the neuronal density, we have performed stereological analysis on Nissl-stained and immunohistochemical slides of positive markers. The stereology data were also used to develop a three-dimensional map of the spatial distribution of neurons within the STN. The nNOS population exhibited the largest neuronal density. The estimated total number of nNOS STN neurons is 281,308 ± 38,967 (± 13.85%). The STN neuronal subpopulations can be divided into two groups: one with a neuronal density of approximately 3,300 neurons/mm3 and the other with a neuronal density of approximately 2,200 neurons/mm3. The largest density of STN neurons was observed along the ventromedial border of the STN and the density gradually decreased toward the dorsolateral border. In this study, we have demonstrated the presence of 7 neuronal markers in the STN, three of which were not previously described in the human STN. The human STN is a collection of diverse, intermixed neuronal subpopulations, and our data, as far as the cytoarchitectonics is concerned, did not support the tripartite STN subdivision. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Neuroanatomy
Brojčani podacivol. 15, 749390
e-ISSN1662-5129
DOIhttps://doi.org/10.3389/fnana.2021.749390
URN:NBNurn:nbn:hr:105:939063
Datum objave publikacije2021-12-14
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fnana.2021.749390/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-07 08:15:27
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