prikaz prve stranice dokumenta Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
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Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
Redox Biology, 9 (2016); 210-219. https://doi.org/10.1016/j.redox.2016.08.010
Gęgotek, Agnieszka; Nikliński, Jacek; Žarković, Neven; Žarković, Kamelija; Waeg, Georg; Łuczaj, Wojciech; Charkiewicz, Radosław; Skrzydlewska, Elżbieta

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Gęgotek, A., Nikliński, J., Žarković, N., Žarković, K., Waeg, G., Łuczaj, W. ... Skrzydlewska, E. (2016). Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells. Redox Biology, 9., 210-219. doi: 10.1016/j.redox.2016.08.010

Gęgotek, Agnieszka, et al. "Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells." Redox Biology, vol. 9, 2016, str. 210-219. https://doi.org/10.1016/j.redox.2016.08.010

Gęgotek, Agnieszka, Jacek Nikliński, Neven Žarković, Kamelija Žarković, Georg Waeg, Wojciech Łuczaj, Radosław Charkiewicz i Elżbieta Skrzydlewska. "Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells." Redox Biology 9 (2016): 210-219. https://doi.org/10.1016/j.redox.2016.08.010

Gęgotek, A., et al. (2016) 'Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells', Redox Biology, 9, str. 210-219. doi: 10.1016/j.redox.2016.08.010

Gęgotek A, Nikliński J, Žarković N, Žarković K, Waeg G, Łuczaj W, i sur.. Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells. Redox Biology [Internet]. 10.2016. [pristupljeno 14.03.2025.];9:210-219. doi: 10.1016/j.redox.2016.08.010

A. Gęgotek, et al., "Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells", Redox Biology, vol. 9, str. 210-219, Listopad 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:938999. [Citirano: 14.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:938999
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Naslov (engleski)Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
AutorAgnieszka Gęgotek
AutorJacek Nikliński
AutorNeven Žarković
AutorKamelija Žarković
AutorGeorg Waeg
AutorWojciech Łuczaj
AutorRadosław Charkiewicz
AutorElżbieta Skrzydlewska
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The oxidative modifications of bioactive macromolecules have important roles in carcinogenesis. Of particular interest are lipid peroxidation products, which are involved in the activation of Nrf2 and endocannabinoids that affect cancer progression. ----- METHODS: In lung cancer tissues (squamous cell lung carcinoma - SCC and adenocarcinoma - AC), the glutathione peroxidase and catalase activity and glutathione level, together with the expression of Nrf2 and its... Više activators/inhibitors were estimated. The oxidative modifications of DNA (8-hydroxy-2'-deoxyguanosine and N7-methylguanine), endocannabinoids (anandamide and 2- arachidonylglyceriol), their receptors (CB1/2, TRV1, GPR55), phospholipid fatty acids (arachidonic, linoleic and docosahexaenoic), and reactive aldehydes (4-hydroxynonenal, 4-oxononenal and malondialdehyde) were determined. ----- RESULTS: Tumour tissues showed lower antioxidant capacity than healthy tissues, which was accompanied by lower levels of fatty acids and higher levels of reactive aldehydes. Disturbances in antioxidant capacity and enhanced DNA oxidative modifications were observed in 88% of AC patients and 81% of SCC patients. The 4-hydroxynonenal-Histidine adducts were detected in the necrotic and stromal cells in all tumours. These findings were associated with the enhanced Nrf2 activity, especially in AC. The strong difference between the cancer subtypes was evident in the levels of endocannabinoids, with an increase in 89% of SCC and a decrease in 85% of AC patients being observed. Additionally, the increase in the expression of CB1/2 receptors was observed only in 82% of AC, while the expression of VR1 and GPR55 was enhanced in 79% of SCC and 82% of AC patients. ----- CONCLUSIONS: This study shows significant differences in the redox status, Nrf2 pathway and endocannabinoid system between SCC and AC tissues. Understanding the relation between the various lipid mediators and antioxidants in different lung cancer subtypes may be beginning for further research on the effective anticancer therapy. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRedox Biology
Brojčani podacivol. 9, str. 210-219
p-ISSN2213-2317
DOIhttps://doi.org/10.1016/j.redox.2016.08.010
URN:NBNurn:nbn:hr:105:938999
Datum objave publikacije2016-10
URL dokumentahttps://doi.org/10.1016/j.redox.2016.08.010
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:56:28
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