prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats
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Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats
Biomedicines, 9 (2021), 9; 1206. https://doi.org/10.3390/biomedicines9091206
Rašić, Domagoj; Zenko Sever, Anita; Rašić, Fran; Štrbe, Sanja; Rašić, Žarko; Đuzel, Antonija; Duplančić, Božidar; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag; Sever, Marko

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Rašić, D., Zenko Sever, A., Rašić, F., Štrbe, S., Rašić, Ž., Đuzel, A. ... Sever, M. (2021). Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats. Biomedicines, 9. (9). doi: 10.3390/biomedicines9091206

Rašić, Domagoj, et al. "Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats." Biomedicines, vol. 9, br. 9, 2021. https://doi.org/10.3390/biomedicines9091206

Rašić, Domagoj, Anita Zenko Sever, Fran Rašić, Sanja Štrbe, Žarko Rašić, Antonija Đuzel, Božidar Duplančić, et al. "Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats." Biomedicines 9, br. 9 (2021). https://doi.org/10.3390/biomedicines9091206

Rašić, D., et al. (2021) 'Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats', Biomedicines, 9(9). doi: 10.3390/biomedicines9091206

Rašić D, Zenko Sever A, Rašić F, Štrbe S, Rašić Ž, Đuzel A, i sur.. Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats. Biomedicines [Internet]. 13.09.2021. [pristupljeno 22.02.2025.];9(9). doi: 10.3390/biomedicines9091206

D. Rašić, et al., "Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats", Biomedicines, vol. 9, br. 9, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:928758. [Citirano: 22.02.2025.]

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Podaci o radu
Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats
AutorDomagoj Rašić
AutorAnita Zenko Sever
AutorFran Rašić
AutorSanja Štrbe
MBZ: 319335
AutorŽarko Rašić
AutorAntonija Đuzel
AutorBožidar Duplančić
AutorAlenka Boban Blagaić
AutorAnita Škrtić
AutorSven Seiwerth
AutorPredrag Sikirić
AutorMarko Sever
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
With the stable gastric pentadecapeptide BPC 157 therapy known to heal various both external and internal rat fistulas, we attempt to approach vesicovaginal fistula, continuous urine leaking through vagina, bladder stones, and a possible therapy solution among rats with well-formed 2 week-fistulas (vaginal/vesical 4 mm large defects) started with delayed therapy. Subsequent control fistula course (the subsequent 1, 2, 4, and 6 weeks) since beginning revealed the failed healing, fistula leaking,... Više adhesions, urinary leaking through vagina, failed epithelization, collagenization, granulation tissue and neovascularization, increased inflammation, and necrosis. Thereby, the later intervals revealed the persistent inability to sustain even minimal volume, vesical, and vaginal defects and stone formation at the end of the experiment (fistula-time day 56). BPC 157 therapy (10 µg/kg, 10 ng/kg, intraperitoneally once time daily or perorally in drinking water until sacrifice) was initiated with a considerable delay (at 2 weeks after fistula formation). Already within 1 week therapy, all BPC 157 regimens stopped urinary leaking through vagina, reversed the otherwise resistant poor healing course to the increased epithelization, collagenization, granulation tissue and neovascularization, decreased inflammation, and decreased necrosis. Thereby, at later intervals, all BPC 157 rats exhibited a five times larger volume that can be sustained before leaking as in healthy, vesical, and vaginal defects completely closed and no stone formation. Thus, macro/microscopic and functional recovery, and counteracted stone formation. Concluding, BPC 157 therapy’s beneficial effects resulted in healing and no stone formation, with µg- and ng-regimens, either given daily perorally in drinking water or intraperitoneally. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 9, br. 9, 1206
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9091206
URN:NBNurn:nbn:hr:105:928758
Datum objave publikacije2021-09-13
URL dokumentahttps://www.mdpi.com/2227-9059/9/9/1206
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-26 09:13:44
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