prikaz prve stranice dokumenta Pentadecapeptide BPC 157 and the central nervous system
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Pentadecapeptide BPC 157 and the central nervous system
Neural Regeneration Research, 17 (2022), 3; 482-487. https://doi.org/10.4103/1673-5374.320969
Vukojević, Jakša; Milavić, Marija; Perović, Darko; Ilić, Spomenko; Zemba Čilić, Andrea; Đuran, Nataša; Štrbe, Sanja; Zoričić, Zoran; Filipčić, Igor; Brečić, Petrana; Seiwerth, Sven; Sikirić, Predrag

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Vukojević, J., Milavić, M., Perović, D., Ilić, S., Zemba Čilić, A., Đuran, N. ... Sikirić, P. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17. (3), 482-487. doi: 10.4103/1673-5374.320969

Vukojević, Jakša, et al. "Pentadecapeptide BPC 157 and the central nervous system." Neural Regeneration Research, vol. 17, br. 3, 2022, str. 482-487. https://doi.org/10.4103/1673-5374.320969

Vukojević, Jakša, Marija Milavić, Darko Perović, Spomenko Ilić, Andrea Zemba Čilić, Nataša Đuran, Sanja Štrbe, et al. "Pentadecapeptide BPC 157 and the central nervous system." Neural Regeneration Research 17, br. 3 (2022): 482-487. https://doi.org/10.4103/1673-5374.320969

Vukojević, J., et al. (2022) 'Pentadecapeptide BPC 157 and the central nervous system', Neural Regeneration Research, 17(3), str. 482-487. doi: 10.4103/1673-5374.320969

Vukojević J, Milavić M, Perović D, Ilić S, Zemba Čilić A, Đuran N, i sur.. Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research [Internet]. 03.2022. [pristupljeno 15.03.2025.];17(3):482-487. doi: 10.4103/1673-5374.320969

J. Vukojević, et al., "Pentadecapeptide BPC 157 and the central nervous system", Neural Regeneration Research, vol. 17, br. 3, str. 482-487, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:830520. [Citirano: 15.03.2025.]

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Naslov (engleski)Pentadecapeptide BPC 157 and the central nervous system
AutorJakša Vukojević
AutorMarija Milavić
AutorDarko Perović
AutorSpomenko Ilić
MBZ: 318211
AutorAndrea Zemba Čilić
AutorNataša Đuran
AutorSanja Štrbe
MBZ: 319335
AutorZoran Zoričić
AutorIgor Filipčić
AutorPetrana Brečić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and therapy application in the central nervous system disorders, in particular. Firstly, given in the reperfusion, BPC 157 counteracted bilateral clamping of the common carotid arteries-induced stroke, sustained brain neuronal damages were resolved in rats as well as disturbed memory, locomotion, and... Više coordination. This therapy effect supports particular gene expression in hippocampal tissues that appeared in BPC 157-treated rats. Secondly, there are L-NG-nitro arginine methyl ester (L-NAME)- and haloperidol-induced catalepsy as well as the rat acute and chronic models of 'positive-like' schizophrenia symptoms, that BPC 157 counteracted, and resolved the complex relationship of the nitric oxide-system with amphetamine and apomorphine (dopamine agents application), MK-801 (non-competitive antagonist of the N-methyl-D-aspartate receptor) and chronic methamphetamine administration (to induce sensitivity). Thirdly, after rat spinal cord compression, there were advanced healing and functional recovery (counteracted tail paralysis). Likewise, in BPC 157 therapy, there is specific support for each of these topics: counteracted encephalopathies; alleviated vascular occlusion disturbances (stroke); counteracted dopamine disturbances (dopamine receptors blockade, receptors super sensitivity development, or receptor activation, over-release, nigrostriatal damage, vesicles depletion), and nitric oxide-system disturbances ("L-NAME non-responsive, L-arginine responsive," and "L-NAME responsive, L-arginine responsive") (schizophrenia therapy); inflammation reduction, nerve recovery in addition to alleviated hemostasis and vessels function after compression (spinal cord injury therapy). Thus, these disturbances may be all resolved within the same agent's beneficial activity, i.e., the stable gastric pentadecapeptide BPC 157. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeural Regeneration Research
Brojčani podacivol. 17, br. 3, str. 482-487
p-ISSN1673-5374
e-ISSN1876-7958
DOIhttps://doi.org/10.4103/1673-5374.320969
URN:NBNurn:nbn:hr:105:830520
Datum objave publikacije2022-03
URL dokumentahttps://journals.lww.com/10.4103/1673-5374.320969
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2022-05-19 09:28:06
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