prikaz prve stranice dokumenta Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension
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Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension
Biomedicines, 9 (2021), 6; 609. https://doi.org/10.3390/biomedicines9060609
Knežević, Mario; Gojković, Slaven; Krezić, Ivan; Žižek, Helena; Malekinušić, Dominik; Vrdoljak, Borna; Vraneš, Hrvoje; Knežević, Tamara; Barišić, Ivan; Horvat Pavlov, Katarina; Drmić, Domagoj; Staroveški, Miro; Đuzel, Antonija; Rajković, Zoran; Kolak, Toni; Kocman, Ivica; Lovrić, Eva; Milavić, Marija; Sikirić, Sunčana; Tvrdeić, Ante; Patrlj, Leonardo; Štrbe, Sanja; Kokot, Antonio; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Knežević, M., Gojković, S., Krezić, I., Žižek, H., Malekinušić, D., Vrdoljak, B. ... Sikirić, P. (2021). Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension. Biomedicines, 9. (6). doi: 10.3390/biomedicines9060609

Knežević, Mario, et al. "Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension." Biomedicines, vol. 9, br. 6, 2021. https://doi.org/10.3390/biomedicines9060609

Knežević, Mario, Slaven Gojković, Ivan Krezić, Helena Žižek, Dominik Malekinušić, Borna Vrdoljak, Hrvoje Vraneš, et al. "Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension." Biomedicines 9, br. 6 (2021). https://doi.org/10.3390/biomedicines9060609

Knežević, M., et al. (2021) 'Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension', Biomedicines, 9(6). doi: 10.3390/biomedicines9060609

Knežević M, Gojković S, Krezić I, Žižek H, Malekinušić D, Vrdoljak B, i sur.. Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension. Biomedicines [Internet]. 26.05.2021. [pristupljeno 20.02.2025.];9(6). doi: 10.3390/biomedicines9060609

M. Knežević, et al., "Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension", Biomedicines, vol. 9, br. 6, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:822386. [Citirano: 20.02.2025.]

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Naslov (engleski)Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension
AutorMario Knežević
AutorSlaven Gojković
AutorIvan Krezić
AutorHelena Žižek
AutorDominik Malekinušić
AutorBorna Vrdoljak
AutorHrvoje Vraneš
AutorTamara Knežević
AutorIvan Barišić
AutorKatarina Horvat Pavlov
AutorDomagoj Drmić
AutorMiro Staroveški
AutorAntonija Đuzel
AutorZoran Rajković
AutorToni Kolak
AutorIvica Kocman
AutorEva Lovrić
AutorMarija Milavić
AutorSunčana Sikirić
AutorAnte Tvrdeić
AutorLeonardo Patrlj
MBZ: 193495
AutorSanja Štrbe
MBZ: 319335
AutorAntonio Kokot
AutorAlenka Boban Blagaić
AutorAnita Škrtić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta. Previously, when confronted with major vessel occlusion, its effect would rapidly activate collateral vessel pathways and resolve major venous occlusion syndromes (Pringle maneuver ischemia, reperfusion, Budd–Chiari syndrome) in rats. This would overwhelm superior mesenteric artery permanent occlusion,... Više and result in local, peripheral, and central disturbances. ----- Methods: Assessments, for 30 min (gross recording, angiography, ECG, pressure, microscopy, biochemistry, and oxidative stress), included the portal hypertension, caval hypertension, and aortal hypotension, and centrally, the superior sagittal sinus hypertension; systemic arterial and venous thrombosis; ECG disturbances; MDA-tissue increase; and multiple organ lesions and disturbances, including the heart, lung, liver, kidney, and gastrointestinal tract, in particular, as well as brain (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus). BPC 157 therapy (/kg, abdominal bath) (10 µg, 10 ng) was given for a 1-min ligation time. ----- Results: BPC 157 rapidly recruits collateral vessels (inferior anterior pancreaticoduodenal artery and inferior mesenteric artery) that circumvent occlusion and ascertains blood flow distant from the occlusion in the superior mesenteric artery. Portal and caval hypertension, aortal hypotension, and, centrally, superior sagittal sinus hypertension were attenuated or eliminated, and ECG disturbances markedly mitigated. BPC 157 therapy almost annihilated venous and arterial thrombosis. Multiple organ lesions and disturbances (i.e., heart, lung, liver, and gastrointestinal tract, in particular, as well as brain) were largely attenuated. ---- Conclusions: Rats with superior mesenteric artery occlusion may additionally undergo BPC 157 therapy as full counteraction of vascular occlusion-induced multiple organ dysfunction syndrome. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 9, br. 6, 609
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9060609
URN:NBNurn:nbn:hr:105:822386
Datum objave publikacije2021-05-26
URL dokumentahttps://www.mdpi.com/2227-9059/9/6/609
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-04 10:17:01
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