prikaz prve stranice dokumenta Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
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Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
Croatian Medical Journal, 55 (2014), 4; 317-327. https://doi.org/10.3325/cmj.2014.55.317
Orešković, Darko; Klarica, Marijan

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Orešković, D. i Klarica, M. (2014). Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?. Croatian Medical Journal, 55. (4), 317-327. doi: 10.3325/cmj.2014.55.317

Orešković, Darko i Marijan Klarica. "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?." Croatian Medical Journal, vol. 55, br. 4, 2014, str. 317-327. https://doi.org/10.3325/cmj.2014.55.317

Orešković, Darko i Marijan Klarica. "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?." Croatian Medical Journal 55, br. 4 (2014): 317-327. https://doi.org/10.3325/cmj.2014.55.317

Orešković, D. i Klarica, M. (2014) 'Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?', Croatian Medical Journal, 55(4), str. 317-327. doi: 10.3325/cmj.2014.55.317

Orešković D, Klarica M. Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?. Croatian Medical Journal [Internet]. 28.08.2014. [pristupljeno 09.05.2024.];55(4):317-327. doi: 10.3325/cmj.2014.55.317

D. Orešković i M. Klarica, "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?", Croatian Medical Journal, vol. 55, br. 4, str. 317-327, Kolovoz 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:814611. [Citirano: 09.05.2024.]

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Naslov (engleski)Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
AutorDarko Orešković
AutorMarijan Klarica
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The generally accepted hypothesis on cerebrospinal fluid (CSF) hydrodynamics suggests that CSF is actively formed mainly by the choroid plexuses, circulates unidirectionally along the brain ventricles and subarachnoid space, and is passively absorbed mainly into the dural venous sinuses. CSF formation rate (Vf) has been extensively studied using the ventriculo-cisternal perfusion technique and the results have been used as the key evidence confirming the mentioned hypothesis. This technique and the equation for Vf calculation are based on the assumption that the dilution of the indicator substance is a consequence of the newly formed CSF, ie, that a higher CSF formation rate will result in a higher degree of dilution. However, it has been experimentally shown that the indicator substance dilution inside the CSF system does not occur because of a "newly formed" CSF, but as consequence of a number of other factors (departure of substances into the surrounding tissue, flowing around the collecting cannula into the cortical and spinal subarachnoid space, departure into the contralateral ventricle, etc). This technique allows "calculation" of the CSF formation even in dead animals, in an in vitro model, and in any other part of the CSF system outside the ventricles that is being perfused. Therefore, this method is indirect and any dilution of the indicator substance in the perfusate caused by other reasons would result in questionable and often contradictory conclusions regarding CSF formation rates.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 55, br. 4, str. 317-327
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.317
URN:NBNurn:nbn:hr:105:814611
Datum objave publikacije2014-08-28
URL dokumentahttps://doi.org/10.3325/cmj.2014.55.317
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:09:59