Cardiac allograft vasculopathy is the complication that most often develops insidiously and its consequences usually come to light when therapeutic options are already limited, thus it is the major cause of mortality in late post transplantation period. Transplanted patients have denervated hearts, therefore they don't perceive anginal symptoms which make CAV even more difficult to recognize. Various immunological and non-immunological risk factors for CAV development have been identified. Pharmacological therapy has contributed to the reduction of CAV incidence, however once when CAV develops, outcome is generally unfavorable. Diagnose of diastolic dysfunction is more sensitive in discovering subclinical graft failure in contrast to systolic function that remains compensated for a long time. Since worsening of graft's function leads to an increase of pressures in heart chambers, it is to be expected that measurement of right ventricle pressure trough sheath which is placed in that chamber for endomyocardial biopsy during routine post transplantation patients follow up, could aid in the early recognition of the subclinical cardiac graft dysfunction. Besides development of CAV, graft rejection may also have detrimental effects on cardiac hemodynamics in post transplantation period and the increased filling pressure of right ventricle leading to congestion, may cause a deterioration of renal function to which are these patients highly susceptible owing to prior cardio-renal syndrome, frequently present diabetes, nephrotoxic effect of calcineurin inhibitors in the immunosuppressive therapy etc. The primary goal of this research is to determine the correlation between the development of CAV and hemodynamic abnormalities registered during the post transplantation follow up. In addition, the association between the graft rejection and hemodynamic parameters of right ventricle dysfunction is going to be investigated as well as an association between the increased pressure in the right ventricle and the development of renal dysfunction in patients after heart transplantation.