prikaz prve stranice dokumenta FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
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FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
Croatian Medical Journal, 61 (2020), 6; 547-555. https://doi.org/10.3325/cmj.2020.61.547
Artuković, Marinko; Ikić Matijašević, Marina; Markotić, Antonio; Šućur, Alan; Grcevic, Danka; Kovačić, Nataša; Flegar, Darja; Stipić Marković, Asja; Šisl, Dino; Artuković, Irena; Kelava, Tomislav

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Artuković, M., Ikić Matijašević, M., Markotić, A., Šućur, A., Grcevic, D., Kovačić, N. ... Kelava, T. (2020). FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population. Croatian Medical Journal, 61. (6), 547-555. doi: 10.3325/cmj.2020.61.547

Artuković, Marinko, et al. "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population." Croatian Medical Journal, vol. 61, br. 6, 2020, str. 547-555. https://doi.org/10.3325/cmj.2020.61.547

Artuković, Marinko, Marina Ikić Matijašević, Antonio Markotić, Alan Šućur, Danka Grcevic, Nataša Kovačić, Darja Flegar, et al. "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population." Croatian Medical Journal 61, br. 6 (2020): 547-555. https://doi.org/10.3325/cmj.2020.61.547

Artuković, M., et al. (2020) 'FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population', Croatian Medical Journal, 61(6), str. 547-555. doi: 10.3325/cmj.2020.61.547

Artuković M, Ikić Matijašević M, Markotić A, Šućur A, Grcevic D, Kovačić N, i sur.. FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population. Croatian Medical Journal [Internet]. 31.12.2020. [pristupljeno 12.04.2024.];61(6):547-555. doi: 10.3325/cmj.2020.61.547

M. Artuković, et al., "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population", Croatian Medical Journal, vol. 61, br. 6, str. 547-555, Prosinac 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:713088. [Citirano: 12.04.2024.]

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Podaci o radu
Naslov (engleski)FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
AutorMarinko Artuković
AutorMarina Ikić Matijašević
AutorAntonio Markotić
AutorAlan Šućur
AutorDanka Grcevic
AutorNataša Kovačić
AutorDarja Flegar
AutorAsja Stipić Marković
AutorDino Šisl
AutorIrena Artuković
AutorTomislav Kelava
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Aim: To investigate the association of FasL gene polymorphism (rs763110) with rheumatoid arthritis occurrence, disease activity, and tumor necrosis factor-α (TNF-α) plasma concentration in Croatian patients, and to conduct an updated meta-analysis. ----- Methods: This cross-sectional study enrolled 81 patients with rheumatoid arthritis and 94 control patients. After the assessment of the Disease Activity Score (DAS)-28, blood was taken for analysis. DNA was isolated from the whole blood to determine FasL polymorphism (rs763110) by polymerase chain reaction. Protein levels of TNF-α were determined with ELISA. After a detailed literature search, we conducted an updated meta-analysis using the Review Manager 5 software. ----- Results: Rheumatoid arthritis patients had significantly higher TNF-α concentration in plasma (1.65 [1.2-2.42] pg/mL) than controls (0.99 [0.77-1.35] pg/mL, P<0.001). The FasL rs763110 polymorphism was not associated with rheumatoid arthritis occurrence in either codominant, dominant, recessive, overdominant, or log additive model. Furthermore, the rs763110 genotype was not associated with DAS 28 score or TNF-α concentration. After we added our results to an updated meta-analysis, the significant association previously reported for Western Eurasians was abolished. ----- Conclusion: Our data suggest that the association between FasL rs763110 polymorphism and RA susceptibility in Western Eurasians observed in previous studies might be overestimated and should be limited to the population of Southwestern Asia until further investigations are performed.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 61, br. 6, str. 547-555
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.547
URN:NBNurn:nbn:hr:105:713088
Datum objave publikacije2020-12-31
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821374/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-02-25 10:34:46