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Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation
Journal of Clinical Medicine, 12 (2023), 19; 6246. https://doi.org/10.3390/jcm12196246
Golubić, Karlo; Angebrandt Belošević, Petra; Slišković, Ana Marija; Grubić, Zorana; Štingl Janković, Katarina; Radeljić, Vjekoslav; Delić Brkljačić, Diana

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Golubić, K., Angebrandt Belošević, P., Slišković, A. M., Grubić, Z., Štingl Janković, K., Radeljić, V. i Delić Brkljačić, D. (2023). Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation. Journal of Clinical Medicine, 12. (19). doi: 10.3390/jcm12196246

Golubić, Karlo, et al. "Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation." Journal of Clinical Medicine, vol. 12, br. 19, 2023. https://doi.org/10.3390/jcm12196246

Golubić, Karlo, Petra Angebrandt Belošević, Ana Marija Slišković, Zorana Grubić, Katarina Štingl Janković, Vjekoslav Radeljić i Diana Delić Brkljačić. "Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation." Journal of Clinical Medicine 12, br. 19 (2023). https://doi.org/10.3390/jcm12196246

Golubić, K., et al. (2023) 'Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation', Journal of Clinical Medicine, 12(19). doi: 10.3390/jcm12196246

Golubić K, Angebrandt Belošević P, Slišković AM, Grubić Z, Štingl Janković K, Radeljić V, i sur.. Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation. Journal of Clinical Medicine [Internet]. 28.09.2023. [pristupljeno 13.03.2025.];12(19). doi: 10.3390/jcm12196246

K. Golubić, et al., "Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation", Journal of Clinical Medicine, vol. 12, br. 19, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:655659. [Citirano: 13.03.2025.]

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Naslov (engleski)Serum Fibrinogen and Renal Dysfunction as Important Predictors of Left Atrial Thrombosis in Patients with Atrial Fibrillation
AutorKarlo Golubić
AutorPetra Angebrandt Belošević
AutorAna Marija Slišković
AutorZorana Grubić
AutorKatarina Štingl Janković
AutorVjekoslav Radeljić
AutorDiana Delić Brkljačić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: As has been shown previously, patients with atrial fibrillation (AF) who have left atrial thrombus (LAT) also have elevated plasma concentrations of fibrinogen. In this study, we tried to determine if this is the consequence of a genetic trait and whether elevated concentrations of fibrinogen could be used to predict LAT in patients with AF. Methods: We recruited 181 consecutive patients scheduled for pulmonary vein isolation (PVI) or direct current cardioversion. The primary... Više endpoint was the presence of LAT on transesophageal echocardiography (TOE). We recorded routine clinical and biochemical data as well as the polymorphism type of the fibrinogen gene for the β chain. To control potentially interfering variables, we performed propensity score matching (PSM). Multivariable and univariable logistic regression models (LRM) were computed using the CHA2DS2-Vasc score, the fibrinogen concentration and creatinine clearance as estimated by the Cockcroft-Gault equation. Results: 60 of 181 patients had LAT as detected by TOE. As expected, patients with LAT had significantly higher concentrations of fibrinogen (3.9 vs. 3.6 g/L); p = 0.01 in the unadjusted analysis. After performing PSM, there were no statistically significant differences between the groups, except for creatinine clearance (79.9 vs. 96.8 mL/min); p = 0.01. There were also no differences regarding the -455 G/A βfibrinogen polymorphism distribution between the two groups. After constructing the LRM, we found no performance enhancement for the CHA2DS2-Vasc score by adding the fibrinogen concentration or creatinine clearance alone, but when all three variables were put together, there was a significant improvement in LAT prediction (AUC 0.64 vs. 0.72), p = 0.026. Conclusion: Our study found no evidence of elevated levels of circulating fibrinogen in patients with LAT or a connection between those levels and the A/A and A positive polymorphism. When used together with renal function markers such as creatinine clearance, plasma fibrinogen concentrations can provide additional power to the CHA2DS2-Vasc score for predicting LAT. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 12, br. 19, 6246
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm12196246
URN:NBNurn:nbn:hr:105:655659
Datum objave publikacije2023-09-28
URL dokumentahttps://www.mdpi.com/2077-0383/12/19/6246
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-17 08:34:28
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