prikaz prve stranice dokumenta Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
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Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics, 113 (2022), 4; 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021
(International Germ Cell Cancer Collaborative Group) Terbuch, Angelika; Posch, Florian; Bauernhofer, Thomas; Jost, Philipp J.; Partl, Richard; Stranzl-Lawatsch, Heidi; Baciarello, Giulia; Fizazi, Karim; Giannatempo, Patrizia; Verzoni, Elena; Sweeney, Christopher; Ravi, Praful; Tran, Ben; Basso, Umberto; White, Jeff; Vincenzi, Bruno; Oing, Christoph; Cutuli, Hernan Javier; Dieckmann, Klaus Peter; Gamulin, Marija; Chovanec, Michal; Fankhauser, Christian Daniel; Heidenreich, Axel; Mohamad, Osama; Thibault, Constance; Fischer, Stefanie; Gillessen, Silke Više autora...

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Terbuch, A., Posch, F., Bauernhofer, T., Jost, P. J., Partl, R., Stranzl Lawatsch, H. ... Gillessen, S. (2022). Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics, 113. (4), 825-832. doi: 10.1016/j.ijrobp.2022.03.021

Terbuch, Angelika, et al. "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics, vol. 113, br. 4, 2022, str. 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021

Terbuch, Angelika, Florian Posch, Thomas Bauernhofer, Philipp J. Jost, Richard Partl, Heidi Stranzl Lawatsch, Giulia Baciarello, et al. "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics 113, br. 4 (2022): 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021

Terbuch, A., et al. (2022) 'Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy', International Journal of Radiation Oncology*Biology*Physics, 113(4), str. 825-832. doi: 10.1016/j.ijrobp.2022.03.021

Terbuch A, Posch F, Bauernhofer T, Jost PJ, Partl R, Stranzl Lawatsch H, i sur.. Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics [Internet]. 15.07.2022. [pristupljeno 01.05.2024.];113(4):825-832. doi: 10.1016/j.ijrobp.2022.03.021

A. Terbuch, et al., "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy", International Journal of Radiation Oncology*Biology*Physics, vol. 113, br. 4, str. 825-832, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:588653. [Citirano: 01.05.2024.]

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Naslov (engleski)Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
AutorAngelika Terbuch
AutorFlorian Posch
AutorThomas Bauernhofer
AutorPhilipp J. Jost
AutorRichard Partl
AutorHeidi Stranzl-Lawatsch
AutorGiulia Baciarello
AutorKarim Fizazi
AutorPatrizia Giannatempo
AutorElena Verzoni
AutorChristopher Sweeney
AutorPraful Ravi
AutorBen Tran
AutorUmberto Basso
AutorJeff White
AutorBruno Vincenzi
AutorChristoph Oing
AutorHernan Javier Cutuli
AutorKlaus Peter Dieckmann
AutorMarija Gamulin
AutorMichal Chovanec
AutorChristian Daniel Fankhauser
AutorAxel Heidenreich
AutorOsama Mohamad
AutorConstance Thibault
AutorStefanie Fischer
AutorSilke Gillessen
KolaboracijaInternational Germ Cell Cancer Collaborative Group
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KLINIČKU ONKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Purpose: Radiation therapy is a possible treatment strategy for patients with testicular seminoma after orchiectomy in clinical stage I or II disease. Little is known about the outcome of patients who experience a relapse after radiation therapy. ----- Methods and materials: Data from 61 patients who relapsed after adjuvant or curative radiation therapy from 17 centers in 11 countries were collected and retrospectively analyzed. Primary outcomes were disease-free and overall survival. Secondary outcomes were time to relapse, stage at relapse, treatment for relapse, and rate of febrile neutropenia during chemotherapy for relapse. ----- Results: With a median follow-up of 9.9 years (95% confidence interval [CI], 7.5-10.9), we found a 5-year disease-free survival of 90% (95% CI, 79-95) and a 5-year overall survival of 98% (95% CI, 89-100). Sixty-six percent of patients had stage III disease at time of relapse and 93% of patients fell into the good prognosis group per the International Germ Cell Cancer Collaborative Group classification. The median time to relapse after radiation therapy was 15.6 months (95% CI, 12-23). Twenty-two (36%) patients relapsed more than 2 years after radiation therapy and 7 (11.5%) patients relapsed more than 5 years after radiation therapy. One-third of relapses was detected owing to patients' symptoms, whereas two-thirds of relapses were detected during routine follow-up. The majority (93%) of cases were treated with cisplatin-based chemotherapy. The rate of febrile neutropenia during chemotherapy was 35%. Five patients experienced a second relapse. At last follow-up, 55 patients (90%) were alive without disease. Only 1 patient died owing to disease progression. ----- Conclusions: Cisplatin-based chemotherapy for patients with seminoma who have relapsed after treatment with radiation therapy alone leads to excellent outcomes. Patients and physicians should be aware of possible late relapses after radiation therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Radiation Oncology*Biology*Physics
Brojčani podacivol. 113, br. 4, str. 825-832
p-ISSN0360-3016
DOIhttps://doi.org/10.1016/j.ijrobp.2022.03.021
URN:NBNurn:nbn:hr:105:588653
Datum objave publikacije2022-07-15
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0360301622002620
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-15 09:26:34