prikaz prve stranice dokumenta How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry
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How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry
ESC Heart Failure, 10 (2022), 2; 884-894. https://doi.org/10.1002/ehf2.14247
Radhoe, Sumant P.; Veenis, Jesse F.; Jakuš, Nina; Timmermans, Philippe; Pouleur, Anne‐Catherine; Rubís, Pawel; Van Craenenbroeck, Emeline M.; Gaizauskas, Edvinas; Barge‐Caballero, Eduardo; Paolillo, Stefania; Grundmann, Sebastian; D'Amario, Domenico; Braun, Oscar Ö.; Gkouziouta, Aggeliki; Planinć, Ivo; Samardžić, Jure; Meyns, Bart; Droogne, Walter; Wierzbicki, Karol; Holcman, Katarzyna; Flammer, Andreas J.; Gašparović, Hrvoje; Biočina, Bojan; Lund, Lars H.; Miličić, Davor; Ruschitzka, Frank; Čikeš, Maja; Brugts, Jasper J. Više autora...

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Radhoe, S. P., Veenis, J. F., Jakuš, N., Timmermans, P., Pouleur, A., Rubís, P. ... Brugts, J. J. (2022). How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry. ESC Heart Failure, 10. (2), 884-894. doi: 10.1002/ehf2.14247

Radhoe, Sumant P., et al. "How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry." ESC Heart Failure, vol. 10, br. 2, 2022, str. 884-894. https://doi.org/10.1002/ehf2.14247

Radhoe, Sumant P., Jesse F. Veenis, Nina Jakuš, Philippe Timmermans, Anne‐Catherine Pouleur, Pawel Rubís, Emeline M. Van Craenenbroeck, et al. "How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry." ESC Heart Failure 10, br. 2 (2022): 884-894. https://doi.org/10.1002/ehf2.14247

Radhoe, S. P., et al. (2022) 'How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry', ESC Heart Failure, 10(2), str. 884-894. doi: 10.1002/ehf2.14247

Radhoe SP, Veenis JF, Jakuš N, Timmermans P, Pouleur A, Rubís P, i sur.. How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry. ESC Heart Failure [Internet]. 04.2022. [pristupljeno 06.04.2025.];10(2):884-894. doi: 10.1002/ehf2.14247

S. P. Radhoe, et al., "How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry", ESC Heart Failure, vol. 10, br. 2, str. 884-894, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:587237. [Citirano: 06.04.2025.]

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Naslov (engleski)How does age affect outcomes after left ventricular assist device implantation: results from the PCHF‐VAD registry
AutorSumant P. Radhoe
AutorJesse F. Veenis
AutorNina Jakuš
AutorPhilippe Timmermans
AutorAnne‐Catherine Pouleur
AutorPawel Rubís
AutorEmeline M. Van Craenenbroeck
AutorEdvinas Gaizauskas
AutorEduardo Barge‐Caballero
AutorStefania Paolillo
AutorSebastian Grundmann
AutorDomenico D'Amario
AutorOscar Ö. Braun
AutorAggeliki Gkouziouta
AutorIvo Planinć
AutorJure Samardžić
AutorBart Meyns
AutorWalter Droogne
AutorKarol Wierzbicki
AutorKatarzyna Holcman
AutorAndreas J. Flammer
AutorHrvoje Gašparović
AutorBojan Biočina
AutorLars H. Lund
AutorDavor Miličić
AutorFrank Ruschitzka
AutorMaja Čikeš
AutorJasper J. Brugts
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into those <50, 50-64, and ≥65 years old. The primary endpoint was all-cause mortality. Among... Više secondary outcomes were heart failure (HF) hospitalizations, right ventricular (RV) failure, haemocompatibility score, bleeding events, non-fatal thromboembolic events, and device-related infections. Of 562 patients, 184 (32.7%) were <50, 305 (54.3%) were aged 50-64, whereas 73 (13.0%) were ≥65 years old. Median follow-up was 1.1 years. Patients in the oldest age group were significantly more often designated as destination therapy (DT) candidates (61%). A 10 year increase in age was associated with a significantly higher risk of mortality (hazard ratio [HR] 1.34, 95% confidence interval [CI] [1.15-1.57]), intracranial bleeding (HR 1.49, 95% CI [1.10-2.02]), and non-intracranial bleeding (HR 1.30, 95% CI [1.09-1.56]), which was confirmed by a higher mean haemocompatibility score (1.37 vs. 0.77, oldest vs. youngest groups, respectively, P = 0.033). Older patients suffered from less device-related infections requiring systemic antibiotics. No age-related differences were observed in HF-related hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, or RV failure. Conclusions: In the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population. The risks of HF hospitalizations, pump thrombosis, ventricular arrhythmia, or RV failure were comparable. Strikingly, older patients had less device-related infections. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaESC Heart Failure
Brojčani podacivol. 10, br. 2, str. 884-894
p-ISSN2055-5822
e-ISSN2055-5822
DOIhttps://doi.org/10.1002/ehf2.14247
URN:NBNurn:nbn:hr:105:587237
Datum objave publikacije2022-04
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/ehf2.14247
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-06-05 07:37:51
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