Objective: The aim of this paper was to show perception of parents whose children receive treatment for malignant diseases related to interpersonal communication with nurses. The purpose was to identify expectations, difficulties and suggestions for improving parents’ communication with nurses. Method: This paper represents a qualitative study involving ten parents whose children receive treatment at the paediatric Department of Haematology and Oncology of Clinical Hospital Centre Zagreb. The data collection involves conducting qualitative semi-structured interviews, and using qualitative content analysis in process. Results: The research provided four themes: parents’ experience during early treatment of children with malignant diseases; parents' experience during hospital treatment; communication between parents, and the interior arrangement of hospital rooms. Elaboration of each theme is done by using categories that are subdivided into subcategories and codes. For parents’ experience during early treatment, the most important is to set the timely diagnosis and initiate treatment as soon as possible. Parents go through several acceptance stages of the diagnosis. For the second theme, parents’ experience during hospital treatment is crucial for nurses to develop a relationship with children to establish attachment and trust. Communication between nurses and parents whose children receive treatment for malignant diseases is essential part of the process during children’s treatment. Nurses provide 24-hour medical care to ill children and nurses are the most accurate source of information about children’s condition, meaning how the child slept through the night, body temperature levels, received treatment, child’s appetite. Providing timely information to parents decreases parents’ fear and anxiety level. Parents are aware that due to the shortage of doctors at the institute their only option is to ask nurses for information that nurses are not at liberty to disclose. Mutual information exchange between parents is inevitable and necessary. Nevertheless, sometimes these experiences may complicate the acceptance stages since each parent has their own experiences coming from their own perspective. A positive exchange of experiences between parents lead to progress while negative experiences are commonly objections and prejudices. Conclusion: the research concludes the need for improving communication between nurses and parents whose children receive treatment for malignant diseases.