prikaz prve stranice dokumenta Epigenetically inactivated RASSF1A as a tumor biomarker
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Epigenetically inactivated RASSF1A as a tumor biomarker
Bosnian Journal of Basic Medical Sciences, 21 (2021), 4; 386-397. https://doi.org/10.17305/bjbms.2020.5219
Raos, Dora; Ulamec, Monika; Katušić Bojanac, Ana; Bulić-Jakuš, Floriana; Ježek, Davor; Sinčić, Nino

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Raos, D., Ulamec, M., Katušić Bojanac, A., Bulić Jakuš, F., Ježek, D. i Sinčić, N. (2021). Epigenetically inactivated RASSF1A as a tumor biomarker. Bosnian Journal of Basic Medical Sciences, 21. (4), 386-397. doi: 10.17305/bjbms.2020.5219

Raos, Dora, et al. "Epigenetically inactivated RASSF1A as a tumor biomarker." Bosnian Journal of Basic Medical Sciences, vol. 21, br. 4, 2021, str. 386-397. https://doi.org/10.17305/bjbms.2020.5219

Raos, Dora, Monika Ulamec, Ana Katušić Bojanac, Floriana Bulić Jakuš, Davor Ježek i Nino Sinčić. "Epigenetically inactivated RASSF1A as a tumor biomarker." Bosnian Journal of Basic Medical Sciences 21, br. 4 (2021): 386-397. https://doi.org/10.17305/bjbms.2020.5219

Raos, D., et al. (2021) 'Epigenetically inactivated RASSF1A as a tumor biomarker', Bosnian Journal of Basic Medical Sciences, 21(4), str. 386-397. doi: 10.17305/bjbms.2020.5219

Raos D, Ulamec M, Katušić Bojanac A, Bulić Jakuš F, Ježek D, Sinčić N. Epigenetically inactivated RASSF1A as a tumor biomarker. Bosnian Journal of Basic Medical Sciences [Internet]. 01.08.2021. [pristupljeno 11.04.2024.];21(4):386-397. doi: 10.17305/bjbms.2020.5219

D. Raos, M. Ulamec, A. Katušić Bojanac, F. Bulić Jakuš, D. Ježek i N. Sinčić, "Epigenetically inactivated RASSF1A as a tumor biomarker", Bosnian Journal of Basic Medical Sciences, vol. 21, br. 4, str. 386-397, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:567170. [Citirano: 11.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:567170
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Podaci o radu
Naslov (engleski)Epigenetically inactivated RASSF1A as a tumor biomarker
AutorDora Raos
AutorMonika Ulamec
AutorAna Katušić Bojanac
AutorFloriana Bulić-Jakuš
AutorDavor Ježek
AutorNino Sinčić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
RASSF1A, one of the eight isoforms of the RASSF1 gene, is a tumor suppressor gene that influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated by mutations, loss of heterozygosity, and, most commonly, by promoter hypermethylation. Epigenetic inactivation of RASSF1A was detected in various cancer types and led to significant interest; current research on RASSF1A promoter methylation focuses on its roles as an epigenetic tumor biomarker. Typically, researchers analyzed genomic DNA (gDNA) to measure the amount of RASSF1A promoter methylation. Cell-free DNA (cfDNA) from liquid biopsies is a recent development showing promise as an early cancer diagnostic tool using biomarkers, such as RASSF1A. This review discusses the evidence on aberrantly methylated RASSF1A in gDNA and cfDNA from different cancer types and its utility for early cancer diagnosis, prognosis, and surveillance. We compared methylation frequencies of RASSF1A in gDNA and cfDNA in various cancer types. The weaknesses and strengths of these analyses are discussed. In conclusion, although the importance of RASSSF1A methylation to cancer has been established is included in several diagnostic panels, its diagnostic utility is still experimental.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBosnian Journal of Basic Medical Sciences
Brojčani podacivol. 21, br. 4, str. 386-397
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2020.5219
URN:NBNurn:nbn:hr:105:567170
Datum objave publikacije2021-08-01
URL dokumentahttps://www.bjbms.org/ojs/index.php/bjbms/article/view/5219
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-04 10:42:23