prikaz prve stranice dokumenta Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases
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diplomski rad
Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases
2016. urn:nbn:hr:105:561686
Sapina, Ivana
Sveučilište u Zagrebu
Medicinski fakultet

Citirajte ovaj rad

Sapina, I. (2016). Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases (Diplomski rad). Zagreb: Sveučilište u Zagrebu, Medicinski fakultet. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:561686

Sapina, Ivana. "Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases." Diplomski rad, Sveučilište u Zagrebu, Medicinski fakultet, 2016. https://urn.nsk.hr/urn:nbn:hr:105:561686

Sapina, Ivana. "Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases." Diplomski rad, Sveučilište u Zagrebu, Medicinski fakultet, 2016. https://urn.nsk.hr/urn:nbn:hr:105:561686

Sapina, I. (2016). 'Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases', Diplomski rad, Sveučilište u Zagrebu, Medicinski fakultet, citirano: 05.04.2025., https://urn.nsk.hr/urn:nbn:hr:105:561686

Sapina I. Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases [Diplomski rad]. Zagreb: Sveučilište u Zagrebu, Medicinski fakultet; 2016 [pristupljeno 05.04.2025.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:561686

I. Sapina, "Anti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases", Diplomski rad, Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, 2016. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:561686

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Podaci o radu
NaslovAnti-TNF therapy and risko of malignancies and infections in inflammatory rheumatic diseases
AutorIvana Sapina
MentorPorin Perić (mentor)
Član povjerenstvaBranimir Anić (predsjednik povjerenstva)
Član povjerenstvaJasenka Markeljević (član povjerenstva)
Član povjerenstvaPorin Perić (član povjerenstva)
Ustanova koja je dodijelila
akademski / stručni stupanj		Sveučilište u Zagrebu
Medicinski fakultet
Zagreb
Datum i država obrane2016-07-15, Hrvatska
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak
Objective: To evaluate the risk of infections and malignancy in a group of patients with inflammatory rheumatic diseases treated with anti-TNF therapy. Methods: The study involved 79 adult patients with rheumatoid arthritis (RA) and ankylosing spondylitis, psoriatic arthritis or undifferentiated spondyloarthropathy (spondyloarthopathy (SpA)); receiving anti-TNF therapy at the department of Rheumatology and Rehabilitation, Clinical Hospital Center Zagreb. The duration of therapy was a minimum of... Više 1 month, with the mean duration of 32,024,0 months. The infections recorded were infections that appeared during treatment or soon after the treatment was stopped. ----- Results: During the course of therapy 17 patients (21,5%) experienced an infection, with the total number of 21 infections. This resulted in an overall incidence rate (IR) of 9,9/100 patient-years. Of the patients with RA 76,5% developed an infection, which was significantly higher than for patients with SpA (p<0,001). The IR/100 patient-years for all infections in RA patients was 23,7 compared to 2,8 in patients with SpA. Female gender was associated with a significantly higher infection rate (70,6%, p=0,005). There were 8 infections that were considered serious, yielding an IR of 3,8/100 patient-years. There was only one malignancy case in our study. ----- Conclusion: Every fifth patient developed an infection during the course of anti-TNF therapy, and more than one third of all infections were serious. RA and female gender was associated with a significantly increased number of infections. Sakrij dio sažetka
Ključne riječi
Jezikengleski
URN:NBNurn:nbn:hr:105:561686
Studijski programNaziv: Medicina (na engleskom jeziku)
Vrsta studija: sveučilišni
Stupanj studija: integrirani preddiplomski i diplomski
Akademski / stručni naziv: doktor/doktorica medicine (dr. med.)
Vrsta resursaTekst
Način izrade datotekeIzvorno digitalna
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-08-31 08:28:37
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