prikaz prve stranice dokumenta Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
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Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
International Journal of Molecular Sciences, 22 (2021), 16; 8844. https://doi.org/10.3390/ijms22168844
Fabris, Dragana; Karmelić, Ivana; Muharemović, Hasan; Sajko, Tomislav; Jurilj, Mia; Potočki, Slavica; Novak, Ruđer; Vukelić, Željka

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Fabris, D., Karmelić, I., Muharemović, H., Sajko, T., Jurilj, M., Potočki, S. ... Vukelić, Ž. (2021). Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence. International Journal of Molecular Sciences, 22. (16). doi: 10.3390/ijms22168844

Fabris, Dragana, et al. "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence." International Journal of Molecular Sciences, vol. 22, br. 16, 2021. https://doi.org/10.3390/ijms22168844

Fabris, Dragana, Ivana Karmelić, Hasan Muharemović, Tomislav Sajko, Mia Jurilj, Slavica Potočki, Ruđer Novak i Željka Vukelić. "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence." International Journal of Molecular Sciences 22, br. 16 (2021). https://doi.org/10.3390/ijms22168844

Fabris, D., et al. (2021) 'Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence', International Journal of Molecular Sciences, 22(16). doi: 10.3390/ijms22168844

Fabris D, Karmelić I, Muharemović H, Sajko T, Jurilj M, Potočki S, i sur.. Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence. International Journal of Molecular Sciences [Internet]. 17.08.2021. [pristupljeno 17.04.2024.];22(16). doi: 10.3390/ijms22168844

D. Fabris, et al., "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence", International Journal of Molecular Sciences, vol. 22, br. 16, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:528352. [Citirano: 17.04.2024.]

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Naslov (engleski)Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
AutorDragana Fabris
AutorIvana Karmelić
AutorHasan Muharemović
AutorTomislav Sajko
AutorMia Jurilj
AutorSlavica Potočki
AutorRuđer Novak
AutorŽeljka Vukelić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU KEMIJU, BIOKEMIJU I KLINIČKU KEMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal–glial tumor type. We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16–C24) in ceramide portions. The major structurally identified class was tumor-associated GD3 (>50%) with 11 species; GD3 (d18:1/24:0) being the most abundant. The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). The peritumoral tissue ganglioside composition was estimated as normal. Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 22, br. 16, 8844
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22168844
URN:NBNurn:nbn:hr:105:528352
Datum objave publikacije2021-08-17
URL dokumentahttps://www.mdpi.com/1422-0067/22/16/8844
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-05-12 07:30:35