prikaz prve stranice dokumenta Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
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Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
Bone Marrow Transplantation, 58 (2023), 8; 874-880. https://doi.org/10.1038/s41409-023-01966-w
Hirschbühl, Klaus; Labopin, Myriam; Polge, Emmanuelle; Blaise, Didier; Bourhis, Jean Henri; Socié, Gerard; Forcade, Edouard; Yakoub-Agha, Ibrahim; Labussière-Wallet, Hélène; Bethge, Wolfgang; Chevallier, Patrice; Bonnet, Sarah; Stelljes, Matthias; Spyridonidis, Alexandros; Perić, Zinaida; Brissot, Eolia; Savani, Bipin; Giebel, Sebastian; Schmid, Christoph; Ciceri, Fabio; Nagler, Arnon; Mohty, Mohamad Više autora...

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Hirschbühl, K., Labopin, M., Polge, E., Blaise, D., Bourhis, J. H., Socié, G. ... Mohty, M. (2023). Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation, 58. (8), 874-880. doi: 10.1038/s41409-023-01966-w

Hirschbühl, Klaus, et al. "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT." Bone Marrow Transplantation, vol. 58, br. 8, 2023, str. 874-880. https://doi.org/10.1038/s41409-023-01966-w

Hirschbühl, Klaus, Myriam Labopin, Emmanuelle Polge, Didier Blaise, Jean Henri Bourhis, Gerard Socié, Edouard Forcade, et al. "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT." Bone Marrow Transplantation 58, br. 8 (2023): 874-880. https://doi.org/10.1038/s41409-023-01966-w

Hirschbühl, K., et al. (2023) 'Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT', Bone Marrow Transplantation, 58(8), str. 874-880. doi: 10.1038/s41409-023-01966-w

Hirschbühl K, Labopin M, Polge E, Blaise D, Bourhis JH, Socié G, i sur.. Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation [Internet]. 08.2023. [pristupljeno 10.05.2024.];58(8):874-880. doi: 10.1038/s41409-023-01966-w

K. Hirschbühl, et al., "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT", Bone Marrow Transplantation, vol. 58, br. 8, str. 874-880, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:511899. [Citirano: 10.05.2024.]

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Naslov (engleski)Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
AutorKlaus Hirschbühl
AutorMyriam Labopin
AutorEmmanuelle Polge
AutorDidier Blaise
AutorJean Henri Bourhis
AutorGerard Socié
AutorEdouard Forcade
AutorIbrahim Yakoub-Agha
AutorHélène Labussière-Wallet
AutorWolfgang Bethge
AutorPatrice Chevallier
AutorSarah Bonnet
AutorMatthias Stelljes
AutorAlexandros Spyridonidis
AutorZinaida Perić
AutorEolia Brissot
AutorBipin Savani
AutorSebastian Giebel
AutorChristoph Schmid
AutorFabio Ciceri
AutorArnon Nagler
AutorMohamad Mohty
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Allogeneic hematopoietic cell transplantation is a potentially curative treatment in high-risk acute lymphoblastic leukemia (ALL). Conditioning regimens based on ≥12 Gray total body irradiation (TBI) represent the current standard in patients ≤45 years, whereas elderly patients frequently receive intermediate intensity conditioning (IIC) to reduce toxicity. To evaluate the role of TBI as a backbone of IIC in ALL, a retrospective, registry-based study included patients >45 years transplanted from matched donors in first complete remission, who had received either fludarabine/TBI 8 Gy (FluTBI8, n = 262), or the most popular, irradiation-free alternative fludarabine/busulfan, comprising busulfan 6.4 mg/kg (FluBu6.4, n = 188) or 9.6 mg/kg (FluBu9.6, n = 51). At two years, overall survival (OS) was 68.5%, 57%, and 62.2%, leukemia-free survival (LFS) was 58%, 42.7%, and 45%, relapse incidence (RI) was 27.2%, 40%, and 30.9%, and non-relapse-mortality (NRM) was 23.1%, 20.7%, and 26.8% for patients receiving FluTBI8Gy, FluBu6.4, and FluBu9.6, respectively. In multivariate analysis, the risk of NRM, acute and chronic graft-versus-host disease was not influenced by conditioning. However, RI was higher after FluBu6.4 (hazard ratio [HR] [95% CI]: 1.85 [1.16-2.95]), and LFS was lower after both FluBu6.4 (HR: 1.56 [1.09-2.23]) and FluBu9.6 (HR: 1.63 [1.02-2.58]) as compared to FluTBI8. Although only resulting in a non-significant advantage in OS, this observation indicates a stronger anti-leukemic efficacy of TBI-based intermediate intensity conditioning.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBone Marrow Transplantation
Brojčani podacivol. 58, br. 8, str. 874-880
p-ISSN0268-3369
e-ISSN1476-5365
DOIhttps://doi.org/10.1038/s41409-023-01966-w
URN:NBNurn:nbn:hr:105:511899
Datum objave publikacije2023-08
URL dokumentahttps://www.nature.com/articles/s41409-023-01966-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-09 11:50:24