Chronic pain is one of the most common causes of disability and the incidence of chronic pain is steadily increasing. Chronic pain is defined as a painful condition lasting longer than 3 to 6 months. There are many theories about the causes of chronic pain, but none provide a full explanation of why it occurs, or how it can be completely prevented. Multimodal pain treatment is defined as the simultaneous application of separate therapeutic interventions with different mechanisms of action within the same or different disciplines focused on different mechanisms of pain. Chronic pain conditions most often have components of multiple different mechanisms of pain, therefore multimodal treatment simultaneously utilizes different methods of treatment such as pharmacological treatment, psychological and physical treatment. Multimodal treatment allows better patient care, but it should be taken into account that individual adaptation to the patient is always necessary and that treatment methods in the case of one patient may not be as effective in the case of another patient. Multimodal treatment of chronic pain achieves better results than using only one method, but continuous evaluation and adaptation of techniques is required. Prevention and early treatment of underlying disease, which is the cause of chronic pain, is important because treating the symptoms without causal treatment is less effective and has many more side effects.