prikaz prve stranice dokumenta Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
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Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
Medicinski glasnik, 15 (2018), 1; 37-45. urn:nbn:hr:105:475901
Uzunović, Selma; Ibrahimagić, Amir; Bedenić, Branka

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Uzunović, S., Ibrahimagić, A. i Bedenić, B. (2018). Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina. Medicinski glasnik, 15. (1), 37-45. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, Selma, et al. "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina." Medicinski glasnik, vol. 15, br. 1, 2018, str. 37-45. https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, Selma, Amir Ibrahimagić i Branka Bedenić. "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina." Medicinski glasnik 15, br. 1 (2018): 37-45. https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, S., Ibrahimagić, A. i Bedenić, B. (2018) 'Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina', Medicinski glasnik, 15(1), str. 37-45. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:475901 (Datum pristupa: 10.05.2024.)

Uzunović S, Ibrahimagić A, Bedenić B. Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina. Medicinski glasnik [Internet]. 01.02.2018. [pristupljeno 10.05.2024.];15(1):37-45. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:475901

S. Uzunović, A. Ibrahimagić i B. Bedenić, "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina", Medicinski glasnik, vol. 15, br. 1, str. 37-45, Veljača 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:475901. [Citirano: 10.05.2024.]

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Naslov (engleski)Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
AutorSelma Uzunović
AutorAmir Ibrahimagić
AutorBranka Bedenić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To investigate the prevalence of derepressed/partly derepressed/inducible and ESBL/AmpC-producing Enterobacter cloacae isolates and treatment options for infections associated with those isolates. ----- METHODS: Antibiotic susceptibility was determined by disc diffusion and broth microdilution according to CLSI guidelines. Doubledisk synergy test (DDST) was performed in order to screen for ESBLs and combined disk test with phenylboronic acid to detect AmpC β -lactamases. PCR was used to detect blaESBL/blacarb genes. Genetic relatedness of the strains was determined by pulsed-fieldgel-electrophoresis (PFGE). ----- RESULTS: Among 14 isolates with the ESBL positive E. cloaceae producing isolates, four (28.6%), nine (64.3%) and one (7.1%) isolates were derepressed/partly derepressed and inducible AmpC producers. Eleven (out of 14) isolates were resistant to cefotaxime, ceftazidime, ceftriaxone, aminoglycosides and fluoroquinolones. All isolates were susceptible to imipenem and meropenem, 79% to cefepime. Five (out of 14; 35.7%) isolates (four derepressed and one inducible AmpC carrying E. cloaceae) were negative in phenotypic test for ESBLs, but positive for broad spectrum TEM-1 β-lactamase. One (out of four derepressed) also produced CMY-2 β-lactamase. Four (out of nine) partly derepressed isolates were positive with the DDST, but did not yield PCR products with primers targeting TEM, SHV and CTX-M beta-lactamases. Four positive partly derepressed isolates carried a blaCTX-M-1 gene, two blaOXA-1 one blaCTX-M-15, OXA-1 and one blaCTX-M-28, OXA-1 (n=1). ----- CONCLUSION: Microbiology laboratories must be able to detect and recognize AmpC-carrying isolates in a timely manner, especially those that are falsely susceptible in vitro to drugs that may be consideredfor therapy of infected patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicinski glasnik
Brojčani podacivol. 15, br. 1, str. 37-45
p-ISSN1840-0132
URN:NBNurn:nbn:hr:105:475901
Datum objave publikacije2018-02-01
URL dokumentahttp://ljkzedo.ba/sites/default/files/Glasnik/MG28/01%20Uzunovic%20925%20A.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:13:00