prikaz prve stranice dokumenta Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma
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Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma
Journal of Clinical Pathology, 69 (2015), 3; 234-239. https://doi.org/10.1136/jclinpath-2015-203130
Lukenda, Adrian; Dotlić, Snježana; Vukojević, Nenad; Šarić, Borna; Vranić, Semir; Žarković, Kamelija

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Lukenda, A., Dotlić, S., Vukojević, N., Šarić, B., Vranić, S. i Žarković, K. (2015). Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma. Journal of Clinical Pathology, 69. (3), 234-239. doi: 10.1136/jclinpath-2015-203130

Lukenda, Adrian, et al. "Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma." Journal of Clinical Pathology, vol. 69, br. 3, 2015, str. 234-239. https://doi.org/10.1136/jclinpath-2015-203130

Lukenda, Adrian, Snježana Dotlić, Nenad Vukojević, Borna Šarić, Semir Vranić i Kamelija Žarković. "Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma." Journal of Clinical Pathology 69, br. 3 (2015): 234-239. https://doi.org/10.1136/jclinpath-2015-203130

Lukenda, A., et al. (2015) 'Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma', Journal of Clinical Pathology, 69(3), str. 234-239. doi: 10.1136/jclinpath-2015-203130

Lukenda A, Dotlić S, Vukojević N, Šarić B, Vranić S, Žarković K. Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma. Journal of Clinical Pathology [Internet]. 03.2015. [pristupljeno 15.03.2025.];69(3):234-239. doi: 10.1136/jclinpath-2015-203130

A. Lukenda, S. Dotlić, N. Vukojević, B. Šarić, S. Vranić i K. Žarković, "Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma", Journal of Clinical Pathology, vol. 69, br. 3, str. 234-239, Ožujak 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:418549. [Citirano: 15.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:418549
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Naslov (engleski)Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma
AutorAdrian Lukenda
AutorSnježana Dotlić
AutorNenad Vukojević
AutorBorna Šarić
AutorSemir Vranić
AutorKamelija Žarković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIMS: The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary body melanoma. ----- METHODS: The immunohistochemical expression of these markers was evaluated using 3,3'-diaminobenzidine tetrahydrochloride (DAB) and 3-amino-9-ethylcarbazole (AEC) chromogens on paraffin-embedded tissue samples from 40... Više patients who underwent enucleation in the period from 1985 through 2000. Thirty-one patients had adequate tissue specimens for the analysis. ----- RESULTS: CD117 overexpression was observed in 12 of the 31 samples (39%) when AEC chromogen was used and in 14 of 26 (54%) samples when DAB was used. CD15 positivity was seen in three out of 30 (10%) samples with AEC and in six out of 26 (23%) samples with DAB. CD20 and CD34 exhibited no positivity in the tested samples. During the average follow-up time of 8.7 years (range 0.5-22 years), 17 patients (55%) died due to metastatic disease. The Kaplan-Meier plots showed a significantly shorter overall and disease-free survival in CD117-positive patients when the AEC chromogen was used. CD15 expression was not associated with patients' survival. In multivariate analysis, patients expressing the CD117 AEC had 4.13 times higher risk of lethal outcome in comparison with CD117 AEC negative patients. ----- CONCLUSIONS: Our retrospective cohort study has for the first time demonstrated a small proportion of CD15-positive uveal melanomas. CD117 AEC overexpression was associated with a worse outcome in patients with choroidal and ciliary body melanoma. Further studies should confirm the validity of these observations and their potential for targeted treatment modalities. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Clinical Pathology
Brojčani podacivol. 69, br. 3, str. 234-239
p-ISSN0021-9746
DOIhttps://doi.org/10.1136/jclinpath-2015-203130
URN:NBNurn:nbn:hr:105:418549
Datum objave publikacije2015-03
URL dokumentahttps://doi.org/10.1136/jclinpath-2015-203130
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:59:03
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