prikaz prve stranice dokumenta HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
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HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
PLoS One, 14 (2019), 2; https://doi.org/10.1371/journal.pone.0211577
Božinović, Ksenija; Sabol, Ivan; Rakušić, Zoran; Jakovčević, Antonia; Šekerija, Mario; Lukinović, Juraj; Prgomet, Drago; Grce, Magdalena

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Božinović, K., Sabol, I., Rakušić, Z., Jakovčević, A., Šekerija, M., Lukinović, J. ... Grce, M. (2019). HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival. PLoS One, 14. (2). doi: 10.1371/journal.pone.0211577

Božinović, Ksenija, et al. "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival." PLoS One, vol. 14, br. 2, 2019. https://doi.org/10.1371/journal.pone.0211577

Božinović, Ksenija, Ivan Sabol, Zoran Rakušić, Antonia Jakovčević, Mario Šekerija, Juraj Lukinović, Drago Prgomet i Magdalena Grce. "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival." PLoS One 14, br. 2 (2019). https://doi.org/10.1371/journal.pone.0211577

Božinović, K., et al. (2019) 'HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival', PLoS One, 14(2). doi: 10.1371/journal.pone.0211577

Božinović K, Sabol I, Rakušić Z, Jakovčević A, Šekerija M, Lukinović J, i sur.. HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival. PLoS One [Internet]. 01.02.2019. [pristupljeno 07.05.2024.];14(2). doi: 10.1371/journal.pone.0211577

K. Božinović, et al., "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival", PLoS One, vol. 14, br. 2, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:414795. [Citirano: 07.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:414795
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Podaci o radu
Naslov (engleski)HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
AutorKsenija Božinović
AutorIvan Sabol
AutorZoran Rakušić
AutorAntonia Jakovčević
AutorMario Šekerija
AutorJuraj Lukinović
AutorDrago Prgomet
AutorMagdalena Grce
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Objectives: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Main HNSCC risk factors are tobacco, alcohol, and high-risk human papillomavirus (HPV). HPV+ oropharyngeal squamous cell cancer (OPSCC) usually have different etiology, increasing incidence and often show an improved survival when compared to HPV-negative cases. The objective of the current study was to retrospectively examine the influence of HPV on the survival of OPSCC patients in a non-Western population setting. ----- Materials and methods: We determined the presence of HPV DNA and/or RNA in 99 formalin-fixed paraffin embedded (FFPE) tissue samples of OPSCC patients treated between 2002 and 2015. Patients were compared based on laboratory, demographic, clinical, life style characteristics and survival. ----- Results: HPV RNA was found in 29.3% cases. However, groups based on HPV data (either RNA, DNA or retrospectively collected p16 staining) did not show significant differences. Overall, 5-year survival was 30% with minimal influence of the HPV positivity. ----- Conclusions: The HPV influence on survival of OPSCC patients is not identical between populations probably due to other factors overshadowing the HPV effect. This should be taken into account when treatment or policy decisions are made in each particular setting.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS One
Brojčani podacivol. 14, br. 2
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0211577
URN:NBNurn:nbn:hr:105:414795
Datum objave publikacije2019-02-01
URL dokumentahttp://doi.org/10.1371/journal.pone.0211577
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:28:34