prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
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Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
Pharmaceuticals, 16 (2023), 5; 676. https://doi.org/10.3390/ph16050676
Sikirić, Predrag; Gojković, Slaven; Krezić, Ivan; Smoday, Ivan Maria; Kalogjera, Luka; Žižek, Helena; Oroz, Katarina; Vraneš, Hrvoje; Vuković, Vlasta; Labidi, May; Štrbe, Sanja; Baketić Orešković, Lidija; Sever, Marko; Tepeš, Marijan; Knežević, Mario; Barišić, Ivan; Blagaić, Vladimir; Vlainić, Josipa; Dobrić, Ivan; Starešinić, Mario; Škrtić, Anita; Jurjević, Ivana; Boban Blagaić, Alenka; Seiwerth, Sven Više autora...

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Sikirić, P., Gojković, S., Krezić, I., Smoday, I. M., Kalogjera, L., Žižek, H. ... Seiwerth, S. (2023). Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function. Pharmaceuticals, 16. (5). doi: 10.3390/ph16050676

Sikirić, Predrag, et al. "Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function." Pharmaceuticals, vol. 16, br. 5, 2023. https://doi.org/10.3390/ph16050676

Sikirić, Predrag, Slaven Gojković, Ivan Krezić, Ivan Maria Smoday, Luka Kalogjera, Helena Žižek, Katarina Oroz, et al. "Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function." Pharmaceuticals 16, br. 5 (2023). https://doi.org/10.3390/ph16050676

Sikirić, P., et al. (2023) 'Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function', Pharmaceuticals, 16(5). doi: 10.3390/ph16050676

Sikirić P, Gojković S, Krezić I, Smoday IM, Kalogjera L, Žižek H, i sur.. Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function. Pharmaceuticals [Internet]. 30.04.2023. [pristupljeno 13.03.2025.];16(5). doi: 10.3390/ph16050676

P. Sikirić, et al., "Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function", Pharmaceuticals, vol. 16, br. 5, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:351067. [Citirano: 13.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:351067
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Podaci o radu
Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function
AutorPredrag Sikirić
AutorSlaven Gojković
AutorIvan Krezić
AutorIvan Maria Smoday
AutorLuka Kalogjera
AutorHelena Žižek
AutorKatarina Oroz
AutorHrvoje Vraneš
AutorVlasta Vuković
AutorMay Labidi
AutorSanja Štrbe
MBZ: 319335
AutorLidija Baketić Orešković
AutorMarko Sever
AutorMarijan Tepeš
AutorMario Knežević
AutorIvan Barišić
AutorVladimir Blagaić
AutorJosipa Vlainić
AutorIvan Dobrić
AutorMario Starešinić
AutorAnita Škrtić
AutorIvana Jurjević
AutorAlenka Boban Blagaić
AutorSven Seiwerth
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Conceptually, a wide beneficial effect, both peripherally and centrally, might have been essential for the harmony of brain–gut and gut–brain axes’ function. Seen from the original viewpoint of the gut peptides’ significance and brain relation, the favorable stable gastric pentadecapeptide BPC 157 evidence in the brain–gut and gut–brain axes’ function might have been presented as a particular interconnected network. These were the behavioral findings (interaction with main systems, anxiolytic,... Više anticonvulsive, antidepressant effect, counteracted catalepsy, and positive and negative schizophrenia symptoms models). Muscle healing and function recovery appeared as the therapeutic effects of BPC 157 on the various muscle disabilities of a multitude of causes, both peripheral and central. Heart failure was counteracted (including arrhythmias and thrombosis), and smooth muscle function recovered. These existed as a multimodal muscle axis impact on muscle function and healing as a function of the brain–gut axis and gut–brain axis as whole. Finally, encephalopathies, acting simultaneously in both the periphery and central nervous system, BPC 157 counteracted stomach and liver lesions and various encephalopathies in NSAIDs and insulin rats. BPC 157 therapy by rapidly activated collateral pathways counteracted the vascular and multiorgan failure concomitant to major vessel occlusion and, similar to noxious procedures, reversed initiated multicausal noxious circuit of the occlusion/occlusion-like syndrome. Severe intracranial (superior sagittal sinus) hypertension, portal and caval hypertensions, and aortal hypotension were attenuated/eliminated. Counteracted were the severe lesions in the brain, lungs, liver, kidney, and gastrointestinal tract. In particular, progressing thrombosis, both peripherally and centrally, and heart arrhythmias and infarction that would consistently occur were fully counteracted and/or almost annihilated. To conclude, we suggest further BPC 157 therapy applications. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 16, br. 5, 676
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16050676
URN:NBNurn:nbn:hr:105:351067
Datum objave publikacije2023-04-30
URL dokumentahttps://www.mdpi.com/1424-8247/16/5/676
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-13 10:12:50
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