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Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
International Journal of Molecular Sciences, 23 (2022), 19; 11626. https://doi.org/10.3390/ijms231911626
Šoštarić, Petra; Vukić, Barbara; Tomašić, Lea; Matak, Ivica

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Šoštarić, P., Vukić, B., Tomašić, L. i Matak, I. (2022). Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats. International Journal of Molecular Sciences, 23. (19). doi: 10.3390/ijms231911626

Šoštarić, Petra, et al. "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats." International Journal of Molecular Sciences, vol. 23, br. 19, 2022. https://doi.org/10.3390/ijms231911626

Šoštarić, Petra, Barbara Vukić, Lea Tomašić i Ivica Matak. "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats." International Journal of Molecular Sciences 23, br. 19 (2022). https://doi.org/10.3390/ijms231911626

Šoštarić, P., et al. (2022) 'Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats', International Journal of Molecular Sciences, 23(19). doi: 10.3390/ijms231911626

Šoštarić P, Vukić B, Tomašić L, Matak I. Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats. International Journal of Molecular Sciences [Internet]. 01.10.2022. [pristupljeno 04.05.2024.];23(19). doi: 10.3390/ijms231911626

P. Šoštarić, B. Vukić, L. Tomašić i I. Matak, "Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats", International Journal of Molecular Sciences, vol. 23, br. 19, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:343506. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:343506
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Naslov (engleski)Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
AutorPetra Šoštarić
AutorBarbara Vukić
AutorLea Tomašić
AutorIvica Matak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Recent animal experiments suggested that centrally transported botulinum toxin type A (BoNT-A) might reduce an abnormal muscle tone, though with an unknown contribution to the dominant peripheral muscular effect observed clinically. Herein, we examined if late BoNT-A antispastic actions persist due to possible central toxin actions in rats. The early effect of intramuscular (i.m.) BoNT-A (5, 2 and 1 U/kg) on a reversible tetanus toxin (TeNT)-induced calf muscle spasm was examined 7 d post-TeNT and later during recovery from flaccid paralysis (TeNT reinjected on day 49 post-BoNT-A). Lumbar intrathecal (i.t.) BoNT-A–neutralizing antiserum was used to discriminate the transcytosis-dependent central toxin action of 5 U/kg BoNT-A. BoNT-A-truncated synaptosomal-associated protein 25 immunoreactivity was examined in the muscles and spinal cord at day 71 post-BoNT-A. All doses (5, 2 and 1 U/kg) induced similar antispastic actions in the early period (days 1–14) post-BoNT-A. After repeated TeNT, only the higher two doses prevented the muscle spasm and associated locomotor deficit. Central trans-synaptic activity contributed to the late antispastic effect of 5 U/kg BoNT-A. Ongoing BoNT-A enzymatic activity was present in both injected muscle and the spinal cord. These observations suggest that the treatment duration in sustained or intermittent muscular hyperactivity might be maintained by higher doses and combined peripheral and central BoNT-A action.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 19, 11626
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms231911626
URN:NBNurn:nbn:hr:105:343506
Datum objave publikacije2022-10-01
ProjektŠifra: UIP-2019-04-8277
Naziv (hrvatski): Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu
Naziv (engleski): Motor effects of clostridial neurotoxins in central nervous system
Kratica: MEFCLO
Voditelj: Ivica Matak
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://www.mdpi.com/1422-0067/23/19/11626
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-22 08:48:51