prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats
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Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats
Biomedicines, 10 (2022), 2; 265. https://doi.org/10.3390/biomedicines10020265
Barišić, Ivan; Balenović, Diana; Udovičić, Mario; Bardak, Darija; Strinić, Dean; Vlainić, Josipa; Vraneš, Hrvoje; Smoday, Ivan Maria; Krezić, Ivan; Milavić, Marija; Sikirić, Sunčana; Uzun, Sandra; Živanović Posilović, Gordana; Štrbe, Sanja; Vukoja, Ivan; Lovrić, Eva; Lozić, Marin; Sever, Marko; Lovrić Benčić, Martina; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Barišić, I., Balenović, D., Udovičić, M., Bardak, D., Strinić, D., Vlainić, J. ... Sikirić, P. (2022). Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats. Biomedicines, 10. (2). doi: 10.3390/biomedicines10020265

Barišić, Ivan, et al. "Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats." Biomedicines, vol. 10, br. 2, 2022. https://doi.org/10.3390/biomedicines10020265

Barišić, Ivan, Diana Balenović, Mario Udovičić, Darija Bardak, Dean Strinić, Josipa Vlainić, Hrvoje Vraneš, et al. "Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats." Biomedicines 10, br. 2 (2022). https://doi.org/10.3390/biomedicines10020265

Barišić, I., et al. (2022) 'Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats', Biomedicines, 10(2). doi: 10.3390/biomedicines10020265

Barišić I, Balenović D, Udovičić M, Bardak D, Strinić D, Vlainić J, i sur.. Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats. Biomedicines [Internet]. 26.01.2022. [pristupljeno 16.03.2025.];10(2). doi: 10.3390/biomedicines10020265

I. Barišić, et al., "Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats", Biomedicines, vol. 10, br. 2, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:330009. [Citirano: 16.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:330009
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Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats
AutorIvan Barišić
AutorDiana Balenović
AutorMario Udovičić
AutorDarija Bardak
AutorDean Strinić
AutorJosipa Vlainić
AutorHrvoje Vraneš
AutorIvan Maria Smoday
AutorIvan Krezić
AutorMarija Milavić
AutorSunčana Sikirić
AutorSandra Uzun
AutorGordana Živanović Posilović
AutorSanja Štrbe
MBZ: 319335
AutorIvan Vukoja
AutorEva Lovrić
AutorMarin Lozić
AutorMarko Sever
AutorMartina Lovrić Benčić
AutorAlenka Boban Blagaić
AutorAnita Škrtić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
We revealed that the stable gastric pentadecapeptide BPC 157, a useful peptide therapy against isoprenaline myocardial infarction, as well as against isoprenaline myocardial reinfarction, may follow the counteraction of the recently described occlusion-like syndrome, induced peripherally and centrally, which was described for the first time in isoprenaline-treated rats. BPC 157 (10 ng/kg, 10 µg/kg i.p.), L-NAME (5 mg/kg i.p.), and L-arginine (200 mg/kg i.p.) were given alone or together at (i)... Više 30 min before or, alternatively, (ii) at 5 min after isoprenaline (75 or 150 mg/kg s.c.). At 30 min after isoprenaline 75 mg/kg s.c., we noted an early multiorgan failure (brain, heart, lung, liver, kidney and gastrointestinal lesions), thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, in its full presentation (or attenuated by BPC 157 therapy (given at 5 min after isoprenaline) via activation of the azygos vein). Further, we studied isoprenaline (75 or 150 mg/kg s.c.) myocardial infarction (1 challenge) and reinfarction (isoprenaline at 0 h and 24 h, 2 challenges) in rats (assessed at the end of the subsequent 24 h period). BPC 157 reduced levels of all necrosis markers, CK, CK-MB, LDH, and cTnT, and attenuated gross (no visible infarcted area) and histological damage, ECG (no ST-T ischemic changes), and echocardiography (preservation of systolic left ventricular function) damage induced by isoprenaline. Its effect was associated with a significant decrease in oxidative stress parameters and likely maintained NO system function, providing that BPC 157 interacted with eNOS and COX2 gene expression in a particular way and counteracted the noxious effect of the NOS-blocker, L-NAME. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 2, 265
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10020265
URN:NBNurn:nbn:hr:105:330009
Datum objave publikacije2022-01-26
URL dokumentahttps://www.mdpi.com/2227-9059/10/2/265
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-18 10:26:04
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