prikaz prve stranice dokumenta Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
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Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
European Cells and Materials, 43 (2022); 79-97. https://doi.org/10.22203/eCM.v043a08
Kostešić, Petar; Vukasović Barišić, Andreja; Erjavec, Igor; Pušić, M; Hudetz, Damir; Matičić, Dražen; Vnuk, D; Vučković, Mirta; Ivković, Alan

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Kostešić, P., Vukasović Barišić, A., Erjavec, I., Pušić, M., Hudetz, D., Matičić, D. ... Ivković, A. (2022). Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model. European Cells and Materials, 43., 79-97. doi: 10.22203/eCM.v043a08

Kostešić, Petar, et al. "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model." European Cells and Materials, vol. 43, 2022, str. 79-97. https://doi.org/10.22203/eCM.v043a08

Kostešić, Petar, Andreja Vukasović Barišić, Igor Erjavec, M Pušić, Damir Hudetz, Dražen Matičić, D Vnuk, Mirta Vučković i Alan Ivković. "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model." European Cells and Materials 43 (2022): 79-97. https://doi.org/10.22203/eCM.v043a08

Kostešić, P., et al. (2022) 'Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model', European Cells and Materials, 43, str. 79-97. doi: 10.22203/eCM.v043a08

Kostešić P, Vukasović Barišić A, Erjavec I, Pušić M, Hudetz D, Matičić D, i sur.. Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model. European Cells and Materials [Internet]. 02.03.2022. [pristupljeno 16.04.2024.];43:79-97. doi: 10.22203/eCM.v043a08

P. Kostešić, et al., "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model", European Cells and Materials, vol. 43, str. 79-97, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:328545. [Citirano: 16.04.2024.]

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Podaci o radu
Naslov (engleski)Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
AutorPetar Kostešić
AutorAndreja Vukasović Barišić
AutorIgor Erjavec
AutorM Pušić
AutorDamir Hudetz
AutorDražen Matičić
AutorD Vnuk
AutorMirta Vučković
AutorAlan Ivković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
To date, no single approach to the treatment of osteochondral defects has resulted in satisfactory long-term outcomes, especially in a young and active human population. Emerging innovative tissue engineering strategies, including the use of composite scaffolds, novel cell sources and bioreactors, have shown promising results. However, these techniques need to be validated in translational animal models before they can be implemented in clinical practice. The aim of the present study was to analyse morphological and microarchitectural parameters during subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral grafts in a sheep model. Animals were divided into 4 treatment groups: nasal chondrocyte (NC) autologous osteochondral grafts, articular chondrocyte (AC) autologous osteochondral grafts, cell-free scaffolds (CFS) and empty defects (EDs). After 6 weeks, 3 months and 12 months, bone remodelling was assessed by histology and micro-computed tomography (µCT). Although gradual remodelling and subchondral bone repair were seen in all groups across the time points, the best results were observed in the NC group. This was evidenced by the extent of new tissue formation and its best integration into the surrounding tissue in the NC group at all time points. This also suggested that nasal septum chondrocyte-seeded grafts adapted well to the biomechanical conditions of the loaded joint surface.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Cells and Materials
Brojčani podacivol. 43, str. 79-97
e-ISSN1473-2262
DOIhttps://doi.org/10.22203/eCM.v043a08
URN:NBNurn:nbn:hr:105:328545
Datum objave publikacije2022-03-02
URL dokumentahttps://www.ecmjournal.org/papers/vol43/pdf/v043a08.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-11 11:53:28