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The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
Neuropsychiatric Disease and Treatment, 10 (2014); 1243-1253. https://doi.org/10.2147/NDT.S61415
Grošić, Vladimir; Folnegović Grošić, Petra; Kalember, Petra; Bajs Janović, Maja; Radoš, Marko; Mihanović, Mate; Henigsberg, Neven

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Grošić, V., Folnegović Grošić, P., Kalember, P., Bajs Janović, M., Radoš, M., Mihanović, M. i Henigsberg, N. (2014). The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study. Neuropsychiatric Disease and Treatment, 10., 1243-1253. doi: 10.2147/NDT.S61415

Grošić, Vladimir, et al. "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study." Neuropsychiatric Disease and Treatment, vol. 10, 2014, str. 1243-1253. https://doi.org/10.2147/NDT.S61415

Grošić, Vladimir, Petra Folnegović Grošić, Petra Kalember, Maja Bajs Janović, Marko Radoš, Mate Mihanović i Neven Henigsberg. "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study." Neuropsychiatric Disease and Treatment 10 (2014): 1243-1253. https://doi.org/10.2147/NDT.S61415

Grošić, V., et al. (2014) 'The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study', Neuropsychiatric Disease and Treatment, 10, str. 1243-1253. doi: 10.2147/NDT.S61415

Grošić V, Folnegović Grošić P, Kalember P, Bajs Janović M, Radoš M, Mihanović M, i sur.. The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study. Neuropsychiatric Disease and Treatment [Internet]. 07.07.2014. [pristupljeno 02.05.2024.];10:1243-1253. doi: 10.2147/NDT.S61415

V. Grošić, et al., "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study", Neuropsychiatric Disease and Treatment, vol. 10, str. 1243-1253, Srpanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:304096. [Citirano: 02.05.2024.]

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Naslov (engleski)The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
AutorVladimir Grošić
AutorPetra Folnegović Grošić
AutorPetra Kalember
AutorMaja Bajs Janović
AutorMarko Radoš
AutorMate Mihanović
AutorNeven Henigsberg
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
PURPOSE: To investigate the correlates of a clinical therapeutic response by using the parameters measured by proton magnetic resonance spectroscopy after the administration of atypical antipsychotics. ----- PATIENTS AND METHODS: Twenty-five antipsychotic-naïve first-episode patients with schizophrenia were monitored for 12 months. The patients were evaluated using (1)H magnetic resonance spectroscopy in the dorsolateral prefrontal cortex and Positive and Negative Syndrome Scale, Clinical Global Impression Scale of Severity, Tower of London - Drexel University, Letter-Number Span Test, Trail Making Test A, and Personal and Social Performance Scale. They were administered atypical antipsychotics, starting with quetiapine. In the absence of a therapeutic response, another antipsychotic was introduced. ----- RESULTS: After 12 study months, the N-acetylaspartate/creatine (NAA/Cr) level did not significantly change at the whole-group level. Additional analysis revealed a significant rise in the NAA/Cr level in the study group that stayed on the same antipsychotic throughout the study course (P=0.008) and a significant drop in NAA/Cr in the study group that switched antipsychotics (P=0.005). On the whole-group level, no significant correlations between NAA/Cr values and other scores were found at either baseline or after 12 study months. ----- CONCLUSION: One-year treatment with atypical antipsychotics administered to antipsychotic-naïve patients didn't result in a significant rise in the NAA/Cr ratio. However, a significant rise was witnessed in the study group in which a satisfactory therapeutic response had been achieved with a single antipsychotic administration.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeuropsychiatric Disease and Treatment
Brojčani podacivol. 10, str. 1243-1253
p-ISSN1178-2021
DOIhttps://doi.org/10.2147/NDT.S61415
URN:NBNurn:nbn:hr:105:304096
Datum objave publikacije2014-07-07
URL dokumentahttps://doi.org/10.2147/NDT.S61415
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:17:09