prikaz prve stranice dokumenta Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
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Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
Bone Marrow Transplantation, 57 (2022), 2; 183-190. https://doi.org/10.1038/s41409-021-01502-8
Penack, Olaf; Peczynski, Christophe; Mohty, Mohamad; Yakoub-Agha, Ibrahim; de la Camara, Rafael; Glass, Bertram; Duarte, Rafael F.; Kröger, Nicolaus; Schoemans, Hélène; Koenecke, Christian; Perić, Zinaida; Basak, Grzegorz W.

Citirajte ovaj rad

Penack, O., Peczynski, C., Mohty, M., Yakoub Agha, I., de la Camara, R., Glass, B. ... Basak, G. W. (2022). Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT. Bone Marrow Transplantation, 57. (2), 183-190. doi: 10.1038/s41409-021-01502-8

Penack, Olaf, et al. "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT." Bone Marrow Transplantation, vol. 57, br. 2, 2022, str. 183-190. https://doi.org/10.1038/s41409-021-01502-8

Penack, Olaf, Christophe Peczynski, Mohamad Mohty, Ibrahim Yakoub Agha, Rafael de la Camara, Bertram Glass, Rafael F. Duarte, et al. "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT." Bone Marrow Transplantation 57, br. 2 (2022): 183-190. https://doi.org/10.1038/s41409-021-01502-8

Penack, O., et al. (2022) 'Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT', Bone Marrow Transplantation, 57(2), str. 183-190. doi: 10.1038/s41409-021-01502-8

Penack O, Peczynski C, Mohty M, Yakoub Agha I, de la Camara R, Glass B, i sur.. Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT. Bone Marrow Transplantation [Internet]. 02.2022. [pristupljeno 01.05.2024.];57(2):183-190. doi: 10.1038/s41409-021-01502-8

O. Penack, et al., "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT", Bone Marrow Transplantation, vol. 57, br. 2, str. 183-190, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:255189. [Citirano: 01.05.2024.]

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Naslov (engleski)Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
AutorOlaf Penack
AutorChristophe Peczynski
AutorMohamad Mohty
AutorIbrahim Yakoub-Agha
AutorRafael de la Camara
AutorBertram Glass
AutorRafael F. Duarte
AutorNicolaus Kröger
AutorHélène Schoemans
AutorChristian Koenecke
AutorZinaida Perić
AutorGrzegorz W. Basak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Risk assessment of allogeneic hematopoietic cell transplantation (allo-HCT) is hindered by the lack of current data on comorbidities and outcome. The EBMT identified 38,760 allo-HCT recipients with hematologic malignancies transplanted between 2010 and 2018 from matched sibling and unrelated donors with a full data set of pre-existing comorbidities. Multivariate analyses using the Cox proportional-hazards model including known risk factors for non-relapse mortality (NRM) were performed. We found that pre-existing renal comorbidity had the strongest association with NRM (hazard ratio [HR] 1.85 [95% CI 1.55–2.19]). In addition, the association of multiple pre-existing comorbidities with NRM was significant, including diabetes, infections, cardiac comorbidity, and pulmonary comorbidity. However, the HR of the association of these comorbidities with NRM was relatively low and did not exceed 1.24. Consequently, the risk of NRM was only moderately increased in patients with a high hematopoietic cell transplantation comorbidity index (HCT-CI) ≥ 3 (HR 1.34 [1.26–1.42]). In the current EBMT population, pre-existing non-renal comorbidities determined NRM after allo-HCT to a much lesser extent as compared with the underlying HCT-CI data. Improvements in management and supportive care as well as higher awareness based on the use of HCT-CI may have contributed to this favorable development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBone Marrow Transplantation
Brojčani podacivol. 57, br. 2, str. 183-190
p-ISSN0268-3369
e-ISSN1476-5365
DOIhttps://doi.org/10.1038/s41409-021-01502-8
URN:NBNurn:nbn:hr:105:255189
Datum objave publikacije2022-02
URL dokumentahttps://www.nature.com/articles/s41409-021-01502-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-03-15 09:20:18