prikaz prve stranice dokumenta Effect of clonidine on the cutaneous silent period during spinal anesthesia
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Effect of clonidine on the cutaneous silent period during spinal anesthesia
World Journal of Clinical Cases, 6 (2018), 16; 1136-1145. https://doi.org/10.12998/wjcc.v6.i16.1136
Graf Zupcic, Sandra; Župčić, Miroslav; Duzel, Viktor; Šimurina, Tatjana; Milošević, Milan; Bašić, Silvio; Vuletić, Vladimira; Kapural, Leonardo

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Graf Zupcic, S., Župčić, M., Duzel, V., Šimurina, T., Milošević, M., Bašić, S. ... Kapural, L. (2018). Effect of clonidine on the cutaneous silent period during spinal anesthesia. World Journal of Clinical Cases, 6. (16), 1136-1145. doi: 10.12998/wjcc.v6.i16.1136

Graf Zupcic, Sandra, et al. "Effect of clonidine on the cutaneous silent period during spinal anesthesia." World Journal of Clinical Cases, vol. 6, br. 16, 2018, str. 1136-1145. https://doi.org/10.12998/wjcc.v6.i16.1136

Graf Zupcic, Sandra, Miroslav Župčić, Viktor Duzel, Tatjana Šimurina, Milan Milošević, Silvio Bašić, Vladimira Vuletić i Leonardo Kapural. "Effect of clonidine on the cutaneous silent period during spinal anesthesia." World Journal of Clinical Cases 6, br. 16 (2018): 1136-1145. https://doi.org/10.12998/wjcc.v6.i16.1136

Graf Zupcic, S., et al. (2018) 'Effect of clonidine on the cutaneous silent period during spinal anesthesia', World Journal of Clinical Cases, 6(16), str. 1136-1145. doi: 10.12998/wjcc.v6.i16.1136

Graf Zupcic S, Župčić M, Duzel V, Šimurina T, Milošević M, Bašić S, i sur.. Effect of clonidine on the cutaneous silent period during spinal anesthesia. World Journal of Clinical Cases [Internet]. 16.12.2018. [pristupljeno 20.02.2025.];6(16):1136-1145. doi: 10.12998/wjcc.v6.i16.1136

S. Graf Zupcic, et al., "Effect of clonidine on the cutaneous silent period during spinal anesthesia", World Journal of Clinical Cases, vol. 6, br. 16, str. 1136-1145, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:235333. [Citirano: 20.02.2025.]

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Naslov (engleski)Effect of clonidine on the cutaneous silent period during spinal anesthesia
AutorSandra Graf Zupcic
AutorMiroslav Župčić
AutorViktor Duzel
AutorTatjana Šimurina
AutorMilan Milošević
AutorSilvio Bašić
AutorVladimira Vuletić
AutorLeonardo Kapural
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: To investigate the effect of clonidine on the cutaneous silent period (CSP) during spinal anesthesia. ----- Methods: A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind trial. They did not have neurological disorders and were scheduled for inguinal hernia repair surgery. This trial was registered on ClinicalTrials.gov (NTC03121261). The patients were randomized into two groups with regards to the intrathecally administered solution: (1)... Više 15 mg of 0.5% levobupivacaine with 50 µg of 0.015% clonidine, or (2) 15 mg of 0.5% levobupivacaine alone. There were 34 patients in the levobupivacaine-clonidine (LC) group and 33 patients in the levobupivacaine (L) group. CSP and its latency were measured four times: prior to the subarachnoid block (SAB), after motor block regression to the 0 level of the Bromage scale, with ongoing sensory blockade, and both 6 and 24 h after SAB. ----- Results: Only data from 30 patients in each group were analyzed. There were no significant differences between the groups investigated preoperatively and after 24 h. The CSP of the L group at the time point when the Bromage scale was 0 was 44.8 ± 8.1 ms, while in the LC group it measured 40.2 ± 3.8 ms (P = 0.007). The latency in the L group at the time point when the Bromage scale was 0 was 130.3 ± 10.2 ms, and in the LC group it was 144.7 ± 8.3 ms (P < 0.001). The CSP of the L group after 6 h was 59.6 ± 9.8 ms, while in the LC group it was 44.5 ± 5.0 ms (P < 0.001). The latency in the L group after 6 h was 110.4 ± 10.6 ms, while in LC group it was 132.3 ± 9.7 ms (P < 0.001). ----- Conclusion: Intrathecal addition of clonidine to levobupivacaine for SAB in comparison with levobupivacaine alone results in a diminished inhibitory tonus and shortened CSP. Sakrij dio sažetka
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Clinical Cases
Brojčani podacivol. 6, br. 16, str. 1136-1145
p-ISSN2307-8960
DOIhttps://doi.org/10.12998/wjcc.v6.i16.1136
URN:NBNurn:nbn:hr:105:235333
Datum objave publikacije2018-12-16
URL dokumentahttp://doi.org/10.12998/wjcc.v6.i16.1136
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:34:36
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