prikaz prve stranice dokumenta The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study
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The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study
Frontiers in Immunology, 14 (2023); 1284031. https://doi.org/10.3389/fimmu.2023.1284031
Drulović, Jelena; Pekmezović, Tatjana; Tamas, Olivera; Adamec, Ivan; Aleksic, Dejan; Andabaka, Marko; Bašić Kes, Vanja; Butković Soldo, Silva; Čukić, Mirjana; Despinić, Livija; Dinčić, Evica; Djelilovic Vranic, Jasminka; Grgic, Sanja; Habek, Mario; Hristova, Sonya Ivanova; Ivanovic, Jovana; Jovanovic, Aleksa; Jovicevic, Vanja; Krbot Skorić, Magdalena; Kuzmanovski, Igor; Maric, Gorica; Mesaros, Sarlota; Milanov, Ivan Gospodinov; Miletic Drakulic, Svetlana; Sinanovic, Osman; Škarpa Prpić, Ingrid; Sremec, Josip; Tadic, Daliborka; Toncev, Gordana; Sokic, Dragoslav Više autora...

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Drulović, J., Pekmezović, T., Tamas, O., Adamec, I., Aleksic, D., Andabaka, M. ... Sokic, D. (2023). The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study. Frontiers in Immunology, 14.. doi: 10.3389/fimmu.2023.1284031

Drulović, Jelena, et al. "The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study." Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.1284031

Drulović, Jelena, Tatjana Pekmezović, Olivera Tamas, Ivan Adamec, Dejan Aleksic, Marko Andabaka, Vanja Bašić Kes, et al. "The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study." Frontiers in Immunology 14 (2023). https://doi.org/10.3389/fimmu.2023.1284031

Drulović, J., et al. (2023) 'The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study', Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1284031

Drulović J, Pekmezović T, Tamas O, Adamec I, Aleksic D, Andabaka M, i sur.. The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study. Frontiers in Immunology [Internet]. 11.2023. [pristupljeno 13.03.2025.];14. doi: 10.3389/fimmu.2023.1284031

J. Drulović, et al., "The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study", Frontiers in Immunology, vol. 14, Studeni 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:219009. [Citirano: 13.03.2025.]

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Naslov (engleski)The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study
AutorJelena Drulović
AutorTatjana Pekmezović
AutorOlivera Tamas
AutorIvan Adamec
AutorDejan Aleksic
AutorMarko Andabaka
AutorVanja Bašić Kes
AutorSilva Butković Soldo
AutorMirjana Čukić
AutorLivija Despinić
AutorEvica Dinčić
AutorJasminka Djelilovic Vranic
AutorSanja Grgic
AutorMario Habek
AutorSonya Ivanova Hristova
AutorJovana Ivanovic
AutorAleksa Jovanovic
AutorVanja Jovicevic
AutorMagdalena Krbot Skorić
AutorIgor Kuzmanovski
AutorGorica Maric
AutorSarlota Mesaros
AutorIvan Gospodinov Milanov
AutorSvetlana Miletic Drakulic
AutorOsman Sinanovic
AutorIngrid Škarpa Prpić
AutorJosip Sremec
AutorDaliborka Tadic
AutorGordana Toncev
AutorDragoslav Sokic
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Introduction: The health-related quality of life (HRQoL) of people with (Pw) multiple sclerosis (MS) is usually deteriorated. It has been recently suggested that comorbidities may have the negative influence on the quality of life of the PwMS, but according to the best of our knowledge, only one study investigated, although in a very small cohort, the impact of individual comorbidity on the quality of life of PwMS. The aim of our investigation was to assess, in an international, multicentric... Više study, the impact of comorbid seizure/epilepsy on the HRQoL in PwMS. Methods: We conducted cross-sectional study at numerous neurological centers in Serbia, Croatia, Bulgaria, Montenegro, Northern Macedonia, and Bosnia and Herzegovina (Federation of Bosnia and Herzegovina and Republic of Srpska). For each patient, demographic and clinical data were collected, including Expanded disability status scale (EDSS) score. Beck Depression Inventory (BDI) and the 36-Item Short Form Health Survey (SF-36) questionnaires were administered to all patients. Results: The study comprised 326 PwMS in total, 127 PwMS with seizure/epilepsy and 209 PwMS without. Both mean Physical health composite (PHC) and mental health composite (MHC) scores, were statistically significantly higher in PwMS without seizure/epilepsy, implicating worse quality of life in PwMS with comorbid seizure/epilepsy. Presence of seizure/epilepsy in pwMS was statistically significant independent predictor of both PHC and MHC, in multivariate linear regression model after adjustment for potential confounding variables. The hierarchical multivariate regression analysis was performed in order to establish the most important predictors of the PHC and MHC of the SF-36, in PwMS with seizure/epilepsy; older age, higher level of disability, as measured by EDSS, higher depression score, drug-resistant epilepsy and shorter time since last seizure were found to significantly predict worse MHC score in PwMS with seizure/epilepsy. Discussion: Our results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 14, 1284031
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2023.1284031
URN:NBNurn:nbn:hr:105:219009
Datum objave publikacije2023-11
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1284031/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-04-04 09:03:43
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