prikaz prve stranice dokumenta N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
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N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
Clinica Chimica Acta, 543 (2023); 117298. https://doi.org/10.1016/j.cca.2023.117298
Nemčić, Matej; Tijardović, Marko; Rudman, Najda; Bulum, Tomislav; Tomić, Martina; Plavša, Branimir; Vučković Rebrina, Sandra; Vučić Lovrenčić, Marijana; Duvnjak, Lea; Morahan, Grant; Gornik, Olga

Citirajte ovaj rad

Nemčić, M., Tijardović, M., Rudman, N., Bulum, T., Tomić, M., Plavša, B. ... Gornik, O. (2023). N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset. Clinica Chimica Acta, 543.. doi: 10.1016/j.cca.2023.117298

Nemčić, Matej, et al. "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset." Clinica Chimica Acta, vol. 543, 2023. https://doi.org/10.1016/j.cca.2023.117298

Nemčić, Matej, Marko Tijardović, Najda Rudman, Tomislav Bulum, Martina Tomić, Branimir Plavša, Sandra Vučković Rebrina, et al. "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset." Clinica Chimica Acta 543 (2023). https://doi.org/10.1016/j.cca.2023.117298

Nemčić, M., et al. (2023) 'N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset', Clinica Chimica Acta, 543. doi: 10.1016/j.cca.2023.117298

Nemčić M, Tijardović M, Rudman N, Bulum T, Tomić M, Plavša B, i sur.. N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset. Clinica Chimica Acta [Internet]. 15.03.2023. [pristupljeno 11.05.2024.];543. doi: 10.1016/j.cca.2023.117298

M. Nemčić, et al., "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset", Clinica Chimica Acta, vol. 543, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:217826. [Citirano: 11.05.2024.]

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Podaci o radu
Naslov (engleski)N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
AutorMatej Nemčić
AutorMarko Tijardović
AutorNajda Rudman
AutorTomislav Bulum
AutorMartina Tomić
AutorBranimir Plavša
AutorSandra Vučković Rebrina
AutorMarijana Vučić Lovrenčić
AutorLea Duvnjak
AutorGrant Morahan
AutorOlga Gornik
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Objective: Previously we have shown that plasma protein N-glycosylation is changed in children at the onset of type 1 diabetes. In this study, we aim to identify N-glycan changes in adults with T1DM, compare them to those in children, and investigate their associations with disease duration, complications, glycaemic status, and smoking. Methods: Serum protein N-glycans from 200 adults with type 1 diabetes and 298 healthy controls were analysed using ultra-high performance liquid chromatography and divided into 39 directly measured glycan groups from which 16 derived traits were calculated. Results: Compared to healthy controls, subjects with type 1 diabetes showed differences in 19 glycan groups and a decrease in monogalactosylated, an increase in digalactosylated, monosialylated, and antennary fucosylated derived traits, from which changes in monogalactosylation and seven directly measured traits overlapped with previously reported in children. Changes in four directly measured and two derived traits previously seen in children were not detected in adults. HbA1c was positively associated with sialylated and highly branched structures, whereas N-glycome was not influenced by disease duration or diabetic complications. Conclusions: Our results suggest potential N-glycome involvement in different stages of type 1 diabetes, including processes underlying its development, the disease itself, as well as those occurring after disease establishment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinica Chimica Acta
Brojčani podacivol. 543, 117298
p-ISSN0009-8981
DOIhttps://doi.org/10.1016/j.cca.2023.117298
URN:NBNurn:nbn:hr:105:217826
Datum objave publikacije2023-03-15
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0009898123001006
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-01-11 10:00:04