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Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study
Journal of Personalized Medicine, 14 (2024), 4; 433. https://doi.org/10.3390/jpm14040433
Sokol Karadjole, Vesna; D’Amato, Antonio; Milošević, Milan; Herman, Mislav; Mikuš, Mislav; Laganà, Antonio Simone; Chiantera, Vito; Etrusco, Andrea

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Sokol Karadjole, V., D’Amato, A., Milošević, M., Herman, M., Mikuš, M., Laganà, A. S. ... Etrusco, A. (2024). Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study. Journal of Personalized Medicine, 14. (4). doi: 10.3390/jpm14040433

Sokol Karadjole, Vesna, et al. "Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study." Journal of Personalized Medicine, vol. 14, br. 4, 2024. https://doi.org/10.3390/jpm14040433

Sokol Karadjole, Vesna, Antonio D’Amato, Milan Milošević, Mislav Herman, Mislav Mikuš, Antonio Simone Laganà, Vito Chiantera i Andrea Etrusco. "Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study." Journal of Personalized Medicine 14, br. 4 (2024). https://doi.org/10.3390/jpm14040433

Sokol Karadjole, V., et al. (2024) 'Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study', Journal of Personalized Medicine, 14(4). doi: 10.3390/jpm14040433

Sokol Karadjole V, D’Amato A, Milošević M, Herman M, Mikuš M, Laganà AS, i sur.. Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study. Journal of Personalized Medicine [Internet]. 19.04.2024. [pristupljeno 01.04.2025.];14(4). doi: 10.3390/jpm14040433

V. Sokol Karadjole, et al., "Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study", Journal of Personalized Medicine, vol. 14, br. 4, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:207762. [Citirano: 01.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:207762
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Podaci o radu
Naslov (engleski)Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study
AutorVesna Sokol Karadjole
AutorAntonio D’Amato
AutorMilan Milošević
AutorMislav Herman
AutorMislav Mikuš
AutorAntonio Simone Laganà
AutorVito Chiantera
AutorAndrea Etrusco
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA GINEKOLOGIJU I OPSTETRICIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Medicina rada i športa
Sažetak (engleski)
Background: Despite pregnancy’s hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted... Više for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval—CI 52.4–70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4–18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4–18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Personalized Medicine
Brojčani podacivol. 14, br. 4, 433
e-ISSN2075-4426
DOIhttps://doi.org/10.3390/jpm14040433
URN:NBNurn:nbn:hr:105:207762
Datum objave publikacije2024-04-19
URL dokumentahttps://www.mdpi.com/2075-4426/14/4/433
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-03 09:33:10
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