prikaz prve stranice dokumenta Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease
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Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease
Ultrasound in Medicine & Biology, 33 (2007), 6; 863-869. https://doi.org/10.1016/j.ultrasmedbio.2007.01.003
Turk, Nikša; Kaštelan, Darko; Čuković-Čavka, Silvija; Kraljević, Ivana; Koršić, Mirko; Vucelić, Boris

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Turk, N., Kaštelan, D., Čuković Čavka, S., Kraljević, I., Koršić, M. i Vucelić, B. (2007). Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease. Ultrasound in Medicine & Biology, 33. (6), 863-869. doi: 10.1016/j.ultrasmedbio.2007.01.003

Turk, Nikša, et al. "Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease." Ultrasound in Medicine & Biology, vol. 33, br. 6, 2007, str. 863-869. https://doi.org/10.1016/j.ultrasmedbio.2007.01.003

Turk, Nikša, Darko Kaštelan, Silvija Čuković Čavka, Ivana Kraljević, Mirko Koršić i Boris Vucelić. "Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease." Ultrasound in Medicine & Biology 33, br. 6 (2007): 863-869. https://doi.org/10.1016/j.ultrasmedbio.2007.01.003

Turk, N., et al. (2007) 'Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease', Ultrasound in Medicine & Biology, 33(6), str. 863-869. doi: 10.1016/j.ultrasmedbio.2007.01.003

Turk N, Kaštelan D, Čuković Čavka S, Kraljević I, Koršić M, Vucelić B. Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease. Ultrasound in Medicine & Biology [Internet]. 2007. [pristupljeno 09.04.2025.];33(6):863-869. doi: 10.1016/j.ultrasmedbio.2007.01.003

N. Turk, D. Kaštelan, S. Čuković Čavka, I. Kraljević, M. Koršić i B. Vucelić, "Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease", Ultrasound in Medicine & Biology, vol. 33, br. 6, str. 863-869, 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:192057. [Citirano: 09.04.2025.]

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Naslov (engleski)Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease
AutorNikša Turk
AutorDarko Kaštelan
AutorSilvija Čuković-Čavka
AutorIvana Kraljević
AutorMirko Koršić
AutorBoris Vucelić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A high incidence of bone disease in patients with inflammatory bowel disease (IBD) requires frequent monitoring of skeletal status and, for that reason, evaluation of radiation-free technology is an issue of interest. Our objective was to appraise the parameters of calcaneal quantitative ultrasound (QUS): broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (QUI), and establish their t-score values to investigate discriminatory ability of QUS in IBD patients with... Više metabolic bone disease. The study included 126 patients (Crohn's disease [n = 94] and ulcerative colitis [n = 32]), and 228 age- and sex-matched healthy volunteers. Bone status was evaluated on the same day by calcaneal QUS and dual-energy x-ray absorptiometry (DXA) at spine (L1-L4) and total hip. All QUS measurements were lower in patients compared with healthy controls (BUA p < 0.001; SOS p < 0.001; QUI p < 0.001) and correlated significantly but inversely with disease duration (r = -0.3, p = 0.002). There was no difference with respect to type of disease (Crohn's disease or ulcerative colitis) or corticosteroid therapy. All three QUS t-scores were significantly lower in patients who had previously sustained fragile fractures (n = 28) than in those without fracture in their history (n = 98) (t-scores: BUA -2.0 vs. -1.3, p = 0.008; SOS -2.1 vs. -1.4, p = 0.02: QUI -2.3 vs. -1.5, p = 0.009). Axial DXA was not significantly different between the fracture and nonfracture patients (-1.7 vs. -1.2, p = 0.1), whereas total hip DXA showed a discriminatory power between the two (-1.6 vs. -0.7, p = 0.001). Patients with t-score < -1.0 scanned by DXA were classified as bone disease. The sensitivity of QUS to identify bone disease was 93% and specificity 63%. The sensitivity of QUS to detect osteopenia was 84% and 72% for osteoporosis. Alternatively, lower negative QUS t-score cutoff </= -1.8 identified 83% of osteoporosis at lumbar spine and 100% at total hip. All three QUS variables had t-scores less than -1.8 when osteoporosis was detected at both spine and hip. However, the subgroup of IBD patients with QUI t-score cutoff </= -1.8 still included 26% of individuals with normal bone status. Calcaneal QUS measurements may identify patients with IBD who are at a higher risk of fracture independently of DXA measurements. However, QUS showed poor agreement with bone status scanned by DXA and a low discriminatory power between osteopenia and osteoporosis. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaUltrasound in Medicine & Biology
Brojčani podacivol. 33, br. 6, str. 863-869
p-ISSN0301-5629
DOIhttps://doi.org/10.1016/j.ultrasmedbio.2007.01.003
URN:NBNurn:nbn:hr:105:192057
Datum objave publikacije2007
URL dokumentahttp://doi.org/10.1016/j.ultrasmedbio.2007.01.003
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:51:22
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