prikaz prve stranice dokumenta Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension
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Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension
PLOS ONE, 19 (2024), 4; e0301416. https://doi.org/10.1371/journal.pone.0301416
Paštrović, Frane; Novak, Ruđer; Grgurević, Ivica; Hrkač, Stela; Salai, Grgur; Žarak, Marko; Grgurević, Lovorka

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Paštrović, F., Novak, R., Grgurević, I., Hrkač, S., Salai, G., Žarak, M. i Grgurević, L. (2024). Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension. PLOS ONE, 19. (4). doi: 10.1371/journal.pone.0301416

Paštrović, Frane, et al. "Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension." PLOS ONE, vol. 19, br. 4, 2024. https://doi.org/10.1371/journal.pone.0301416

Paštrović, Frane, Ruđer Novak, Ivica Grgurević, Stela Hrkač, Grgur Salai, Marko Žarak i Lovorka Grgurević. "Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension." PLOS ONE 19, br. 4 (2024). https://doi.org/10.1371/journal.pone.0301416

Paštrović, F., et al. (2024) 'Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension', PLOS ONE, 19(4). doi: 10.1371/journal.pone.0301416

Paštrović F, Novak R, Grgurević I, Hrkač S, Salai G, Žarak M, i sur.. Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension. PLOS ONE [Internet]. 11.04.2024. [pristupljeno 13.03.2025.];19(4). doi: 10.1371/journal.pone.0301416

F. Paštrović, et al., "Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension", PLOS ONE, vol. 19, br. 4, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:159721. [Citirano: 13.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:159721
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Naslov (engleski)Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension
AutorFrane Paštrović
AutorRuđer Novak
AutorIvica Grgurević
AutorStela Hrkač
AutorGrgur Salai
AutorMarko Žarak
AutorLovorka Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Introduction: Portal hypertension (PH) drives the progression of liver cirrhosis to decompensation and death. Hepatic venous pressure gradient (HVPG) measurement is the standard of PH quantification, and HVPG≥10 mmHg defines clinically significant PH (CSPH). We performed proteomics-based serum profiling to search for a proteomic signature of CSPH in patients with compensated advanced chronic liver disease (cACLD). Materials and methods: Consecutive patients with histologically confirmed cACLD... Više and results of HVPG measurements were prospectively included. Serum samples were pooled according to the presence/absence of CSPH and analysed by liquid chromatography-mass spectrometry. Gene set enrichment analysis was performed, followed by comprehensive literature review for proteins identified with the most striking difference between the groups. Results: We included 48 patients (30 with, and 18 without CSPH). Protein CD44, involved in the inflammatory response, vascular endothelial growth factor C (VEGF-C) and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), both involved in lymphangiogenesis were found solely in the CSPH group. Although identified in both groups, proteins involved in neutrophil extracellular traps (NET) formation, as well as tenascin C, autotaxin and nephronectin which mediate vascular contractility and lymphangiogenesis were more abundant in CSPH. Discussion and conclusion: We propose that altered inflammatory response, including NET formation, vascular contractility and formation of new lymph vessels are key steps in PH development. Proteins such as CD44, VEGF-C, LYVE-1, tenascin C, Plasminogen activator inhibitor 1, Nephronectin, Bactericidal permeability-increasing protein, Autotaxin, Myeloperoxidase and a disintegrin and metalloproteinase with thrombospondin motifs-like protein 4 might be considered for further validation as potential therapeutic targets and candidate biomarkers of CSPH in cACLD. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS ONE
Brojčani podacivol. 19, br. 4, e0301416
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0301416
URN:NBNurn:nbn:hr:105:159721
Datum objave publikacije2024-04-11
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Reproduktivna i regenerativna medicina - istraživanja novih platformi i potencijala
Naziv (engleski): Scientific Center of Excellence for Reproductive and Regenerative Medicine
Kratica: CERRM
Voditelj: Davor Ježek
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://dx.plos.org/10.1371/journal.pone.0301416
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-13 08:00:56
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