prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions
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Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions
Pharmaceuticals, 16 (2023), 7; 1052. https://doi.org/10.3390/ph16071052
Sikirić, Predrag; Kokot, Antonio; Kralj, Tamara; Zlatar, Mirna; Masnec, Sanja; Lazić, Ratimir; Lončarić, Kristina; Oroz, Katarina; Sablić, Marko; Bolješić, Marta; Antunović, Marko; Sikirić, Sunčana; Štrbe, Sanja; Stambolija, Vasilije; Beketić Orešković, Lidija; Kavelj, Ivana; Novosel, Luka; Zubčić, Slavica; Krezić, Ivan; Škrtić, Anita; Jurjević, Ivana; Boban Blagaić, Alenka; Seiwerth, Sven; Starešinić, Mario Više autora...

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Sikirić, P., Kokot, A., Kralj, T., Zlatar, M., Masnec, S., Lazić, R. ... Starešinić, M. (2023). Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions. Pharmaceuticals, 16. (7). doi: 10.3390/ph16071052

Sikirić, Predrag, et al. "Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions." Pharmaceuticals, vol. 16, br. 7, 2023. https://doi.org/10.3390/ph16071052

Sikirić, Predrag, Antonio Kokot, Tamara Kralj, Mirna Zlatar, Sanja Masnec, Ratimir Lazić, Kristina Lončarić, et al. "Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions." Pharmaceuticals 16, br. 7 (2023). https://doi.org/10.3390/ph16071052

Sikirić, P., et al. (2023) 'Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions', Pharmaceuticals, 16(7). doi: 10.3390/ph16071052

Sikirić P, Kokot A, Kralj T, Zlatar M, Masnec S, Lazić R, i sur.. Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions. Pharmaceuticals [Internet]. 24.07.2023. [pristupljeno 01.04.2025.];16(7). doi: 10.3390/ph16071052

P. Sikirić, et al., "Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions", Pharmaceuticals, vol. 16, br. 7, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:152790. [Citirano: 01.04.2025.]

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Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions
AutorPredrag Sikirić
AutorAntonio Kokot
AutorTamara Kralj
AutorMirna Zlatar
AutorSanja Masnec
AutorRatimir Lazić
AutorKristina Lončarić
AutorKatarina Oroz
AutorMarko Sablić
AutorMarta Bolješić
AutorMarko Antunović
AutorSunčana Sikirić
AutorSanja Štrbe
MBZ: 319335
AutorVasilije Stambolija
AutorLidija Beketić Orešković
AutorIvana Kavelj
AutorLuka Novosel
AutorSlavica Zubčić
AutorIvan Krezić
AutorAnita Škrtić
AutorIvana Jurjević
AutorAlenka Boban Blagaić
AutorSven Seiwerth
AutorMario Starešinić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Recently, stable gastric pentadecapeptide BPC 157 therapy by activation of collateral pathways counteracted various occlusion/occlusion-like syndromes, vascular, and multiorgan failure, and blood pressure disturbances in rats with permanent major vessel occlusion and similar procedures disabling endothelium function. Thereby, we revealed BPC 157 cytoprotective therapy with strong vascular rescuing capabilities in glaucoma therapy. With these capabilities, BPC 157 therapy can recover... Više glaucomatous rats, normalize intraocular pressure, maintain retinal integrity, recover pupil function, recover retinal ischemia, and corneal injuries (i.e., maintained transparency after complete corneal abrasion, corneal ulceration, and counteracted dry eye after lacrimal gland removal or corneal insensitivity). The most important point is that in glaucomatous rats (three of four episcleral veins cauterized) with high intraocular pressure, all BPC 157 regimens immediately normalized intraocular pressure. BPC 157-treated rats exhibited normal pupil diameter, microscopically well-preserved ganglion cells and optic nerve presentation, normal fundus presentation, nor- mal retinal and choroidal blood vessel presentation, and normal optic nerve presentation. The one episcleral vein rapidly upgraded to accomplish all functions in glaucomatous rats may correspond with occlusion/occlusion-like syndromes of the activated rescuing collateral pathway (azygos vein direct blood flow delivery). Normalized intraocular pressure in glaucomatous rats corresponded to the counteracted intra-cranial (superior sagittal sinus), portal, and caval hypertension, and aortal hypotension in occlusion/occlusion-like syndromes, were all attenuated/eliminated by BPC 157 therapy. Furthermore, given in other eye disturbances (i.e., retinal ischemia), BPC 157 instantly breaks a noxious chain of events, both at an early stage and an already advanced stage. Thus, we further advocate BPC 157 as a therapeutic agent in ocular disease. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 16, br. 7, 1052
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16071052
URN:NBNurn:nbn:hr:105:152790
Datum objave publikacije2023-07-24
URL dokumentahttps://www.mdpi.com/1424-8247/16/7/1052
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-04 08:30:20
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