OBJECTIVE: The aim of this study was to explore and determine possible benefit of LMWH use during pregnancy in women with thromboprophylaxis indications, regarding increase in rate of term deliveries and live births, decrease in miscarriages number and decrease in maternal and fetal complications due to prothrombotic states. ----- METHODS: This retrospective study was based on collecting personal and family history data of pregnant women, especially data on thromboembolic events, miscarriages and maternal and fetal complications during pregnancy. Thrombophilia factors data also were collected for each pregnant woman. All examinees received LMWH during pregnancy and puerperium. They were categorized in six groups according to the indication for thromboprophylaxis. ----- RESULTS: This study included 58 pregnant women with 61 pregnancies. All pregnancy outcomes were noted. The results demonstrated an increase in the rate of deliveries after pregnancies treated with LMWH, when compared with earlier untreated pregnancies. Five out of six groups registered an increase in number of successful pregnancies as follows: group A for 23.08%, group C for 71.11%, group D for 64.96%, group E for 77.38% and group F for 66.67%. 100% of pregnancies in group B resulted in term delivery, however, as these were the first pregnancies of this women, the comparison could not be made. None of examinees experienced venous thromboembolism during pregnancy and puerperium. ----- CONCLUSION: The results support the thesis of positive effect of thromboprophylaxis during pregnancy on pregnancy outcome in the specific groups of pregnant women. However, further studies including more examinees and the control group would be crucial for drawing correct conclusions regarding the influence of LMWH on pregnancy outcomes. Furthermore, a number of factors not included in this study could have an influence on pregnancy outcome and possible maternal and fetal complications, and should be considered when making conclusions about this study results in order not to overestimate possible benefit of LMWH prophylaxis in pregnancy.