Alcohol related liver disease is associated with excessive alcohol consumption. There are several metabolic pathways for alcohol in the liver, and the main one is through alcohol dehydrogenase. The toxic effect of alcohol on the liver causes pathological changes ranging from fatty liver, through alcoholic steatohepatitis, to the accumulation of connective tissue and the development of cirrhosis, which represents the end stage. Clinical picture depends on the stage of the disease. Fatty liver usually has no symptoms, the main symptom of alcoholic hepatitis is jaundice, and cirrhosis often presents with symptoms that are the result of impaired liver function or developed complications such as portal hypertension. The diagnosis of alcoholic liver disease is based on the clinical picture and laboratory findings, and imaging modalities such as ultrasound, computerized tomography and magnetic resonance imaging. Treatment of the disease is based on abstinence from alcohol and addiction treatment, nutritional support, pharmacological therapy for hepatitis, symptomatic and supportive measures in advanced stages and liver transplantation as the only effective treatment for the final stage of the disease. On the other hand, hepatitis C represents a common liver disease among intravenous drug users. The virus is transmitted through contact with the blood of an infected person, and the liver cells are damaged by a direct cytopathic effect, but also by modulating the immune response of the host. Clinically and pathologically, acute and chronic hepatitis are distinguished, and cirrhosis develops as the final stage of the disease. Most patients with acute hepatitis have no symptoms and develop a chronic form of the disease that is difficult to recognize due to non-specific symptoms, and the first symptoms can often be related to liver failure. The basis for the diagnosis of hepatitis C is a laboratory evidence of specific HCV antibodies and viral RNA. In patients with chronic hepatitis, it is recommended to assess the degree of fibrosis using noninvasive methods. The introduction of direct-acting antiviral drugs has significantly increased the survival of patients.