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Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview
Pharmacogenomics and Personalized Medicine, 14 (2021); 631-653. https://doi.org/10.2147/PGPM.S284615
Švob Štrac, Dubravka; Konjevod, Marcela; Šagud, Marina; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Vuić, Barbara; Šimić, Goran; Vukić, Vana; Mimica, Ninoslav; Pivac, Nela

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Švob Štrac, D., Konjevod, M., Šagud, M., Nikolac Perković, M., Nedić Erjavec, G., Vuić, B. ... Pivac, N. (2021). Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview. Pharmacogenomics and Personalized Medicine, 14., 631-653. doi: 10.2147/PGPM.S284615

Švob Štrac, Dubravka, et al. "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview." Pharmacogenomics and Personalized Medicine, vol. 14, 2021, str. 631-653. https://doi.org/10.2147/PGPM.S284615

Švob Štrac, Dubravka, Marcela Konjevod, Marina Šagud, Matea Nikolac Perković, Gordana Nedić Erjavec, Barbara Vuić, Goran Šimić, Vana Vukić, Ninoslav Mimica i Nela Pivac. "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview." Pharmacogenomics and Personalized Medicine 14 (2021): 631-653. https://doi.org/10.2147/PGPM.S284615

Švob Štrac, D., et al. (2021) 'Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview', Pharmacogenomics and Personalized Medicine, 14, str. 631-653. doi: 10.2147/PGPM.S284615

Švob Štrac D, Konjevod M, Šagud M, Nikolac Perković M, Nedić Erjavec G, Vuić B, i sur.. Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview. Pharmacogenomics and Personalized Medicine [Internet]. 28.05.2021. [pristupljeno 04.04.2025.];14:631-653. doi: 10.2147/PGPM.S284615

D. Švob Štrac, et al., "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview", Pharmacogenomics and Personalized Medicine, vol. 14, str. 631-653, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:099729. [Citirano: 04.04.2025.]

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Podaci o radu
Naslov (engleski)Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview
AutorDubravka Švob Štrac
AutorMarcela Konjevod
AutorMarina Šagud
AutorMatea Nikolac Perković
AutorGordana Nedić Erjavec
AutorBarbara Vuić
AutorGoran Šimić
AutorVana Vukić
AutorNinoslav Mimica
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Alzheimer's disease (AD) is a progressive, complex, and multifactorial neurodegenerative disorder, still without effective and stable therapeutic strategies. Currently, available medications for AD are based on symptomatic therapy, which include acetylcholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonist. Additionally, medications such as antipsychotic drugs, antidepressants, sedative, and hypnotic agents, and mood stabilizers are used for the management of... Više behavioral and psychological symptoms of dementia (BPSD). Clinical research has been extensively investigated treatments focusing on the hallmark pathology of AD, including the amyloid deposition, tau hyperphosphorylation, neuroinflammation, and vascular changes; however, so far without success, as all new potential drugs failed to show significant clinical benefit. The underlying heterogeneous etiology and diverse symptoms of AD suggest that a precision medicine strategy is required, which would take into account the complex genetic, epigenetic, and environmental landscape of each AD patient. The article provides a comprehensive overview of the literature on AD, the current and potential therapy of both cognitive symptoms as well as BPSD, with a special focus on gut microbiota and epigenetic modifications as new emerging drug targets. Their specific patterns could represent the basis for novel individually tailored approaches aimed to optimize precision medicine strategies for AD prevention and treatment. However, the successful application of precision medicine to AD demands a further extensive research of underlying pathological processes, as well as clinical and biological complexity of this multifactorial neurodegenerative disorder. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmacogenomics and Personalized Medicine
Brojčani podacivol. 14, str. 631-653
e-ISSN1178-7066
DOIhttps://doi.org/10.2147/PGPM.S284615
URN:NBNurn:nbn:hr:105:099729
Datum objave publikacije2021-05-28
ProjektŠifra: IP-2019-04-6100
Naziv (hrvatski): Terapijski potencijal neurosteroida i neurotrofina u demenciji
Naziv (engleski): Therapeutic potential of neurosteroids and neurotrophins in dementia
Kratica: TePoNeDe
Voditelj: Dubravka Švob Štrac
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.dovepress.com/personalizing-the-care-and-treatment-of-alzheimers-disease-an-overview-peer-reviewed-fulltext-article-PGPM
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 3.0 (CC BY-NC 3.0)
Datum i vrijeme pohrane2021-10-14 09:04:11
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