prikaz prve stranice dokumenta Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy
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Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy
Current Issues in Molecular Biology, 44 (2022), 5; 1901-1927. https://doi.org/10.3390/cimb44050130
Perović, Darko; Milavić, Marija; Dokuzović, Stjepan; Krezić, Ivan; Gojković, Slaven; Vranes, Hrvoje; Bebek, Igor; Bilić, Vide; Somun, Nenad; Brižić, Ivan; Skorak, Ivan; Hriberski, Klaudija; Sikirić, Sunčana; Lovrić, Eva; Štrbe, Sanja; Kubat, Milovan; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Perović, D., Milavić, M., Dokuzović, S., Krezić, I., Gojković, S., Vranes, H. ... Sikirić, P. (2022). Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy. Current Issues in Molecular Biology, 44. (5), 1901-1927. doi: 10.3390/cimb44050130

Perović, Darko, et al. "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy." Current Issues in Molecular Biology, vol. 44, br. 5, 2022, str. 1901-1927. https://doi.org/10.3390/cimb44050130

Perović, Darko, Marija Milavić, Stjepan Dokuzović, Ivan Krezić, Slaven Gojković, Hrvoje Vranes, Igor Bebek, et al. "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy." Current Issues in Molecular Biology 44, br. 5 (2022): 1901-1927. https://doi.org/10.3390/cimb44050130

Perović, D., et al. (2022) 'Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy', Current Issues in Molecular Biology, 44(5), str. 1901-1927. doi: 10.3390/cimb44050130

Perović D, Milavić M, Dokuzović S, Krezić I, Gojković S, Vranes H, i sur.. Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy. Current Issues in Molecular Biology [Internet]. 27.04.2022. [pristupljeno 10.04.2024.];44(5):1901-1927. doi: 10.3390/cimb44050130

D. Perović, et al., "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy", Current Issues in Molecular Biology, vol. 44, br. 5, str. 1901-1927, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:066238. [Citirano: 10.04.2024.]

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Naslov (engleski)Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy
AutorDarko Perović
AutorMarija Milavić
AutorStjepan Dokuzović
AutorIvan Krezić
AutorSlaven Gojković
AutorHrvoje Vranes
AutorIgor Bebek
AutorVide Bilić
AutorNenad Somun
AutorIvan Brižić
AutorIvan Skorak
AutorKlaudija Hriberski
AutorSunčana Sikirić
AutorEva Lovrić
AutorSanja Štrbe
MBZ: 319335
AutorMilovan Kubat
AutorAlenka Boban Blagaić
AutorAnita Škrtić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA SUDSKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sudska medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury. Besides the demonstrated rapid and sustained recovery (1 year), we showed the particular points of the immediate effect of the BPC 157 therapy that began rapidly after its administration, (i) soon after injury (10 min), or (ii) later (4 days), in the rats with a definitive spinal cord injury. Specifically, in counteracting spinal cord hematoma and swelling, (i) in rats that had undergone acute spinal cord injury, followed by intraperitoneal BPC 157 application at 10 min, we focused on the first 10–30 min post-injury period (assessment of gross, microscopic, and gene expression changes). Taking day 4 post-injury as the definitive injury, (ii) we focused on the immediate effects after the BPC 157 intragastric application over 20 min of the post-therapy period. Comparable long-time recovery was noted in treated rats which had definitive tail paralysis: (iii) the therapy was continuously given per orally in drinking water, beginning at day 4 after injury and lasting one month after injury. BPC 157 rats presented only discrete edema and minimal hemorrhage and increased Nos1, Nos2, and Nos3 values (30 min post-injury, (i)) or only mild hemorrhage, and only discrete vacuolation of tissue (day 4, (ii)). In the day 4–30 post-injury study (iii), BPC 157 rats rapidly presented tail function recovery, and no demyelination process (Luxol fast blue staining).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Issues in Molecular Biology
Brojčani podacivol. 44, br. 5, str. 1901-1927
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb44050130
URN:NBNurn:nbn:hr:105:066238
Datum objave publikacije2022-04-27
URL dokumentahttps://www.mdpi.com/1467-3045/44/5/130
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-07 15:07:46