prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats
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Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats
Frontiers in Pharmacology, 12 (2021); 718147. https://doi.org/10.3389/fphar.2021.718147
Tepeš, Marijan; Gojković, Slaven; Krezić, Ivan; Žižek, Helena; Vraneš, Hrvoje; Madžar, Zrinko; Šantak, Goran; Batelja, Lovorka; Milavić, Marija; Sikirić, Sunčana; Kocman, Ivica; Šimonji, Karol; Samara, Mariam; Knežević, Mario; Barišić, Ivan; Lovrić, Eva; Štrbe, Sanja; Kokot, Antonio; Sjekavica, Ivica; Kolak, Toni; Škrtić, Anita; Seiwerth, Sven; Boban Blagaić, Alenka; Sikirić, Predrag Više autora...

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Tepeš, M., Gojković, S., Krezić, I., Žižek, H., Vraneš, H., Madžar, Z. ... Sikirić, P. (2021). Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats. Frontiers in Pharmacology, 12.. doi: 10.3389/fphar.2021.718147

Tepeš, Marijan, et al. "Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats." Frontiers in Pharmacology, vol. 12, 2021. https://doi.org/10.3389/fphar.2021.718147

Tepeš, Marijan, Slaven Gojković, Ivan Krezić, Helena Žižek, Hrvoje Vraneš, Zrinko Madžar, Goran Šantak, et al. "Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats." Frontiers in Pharmacology 12 (2021). https://doi.org/10.3389/fphar.2021.718147

Tepeš, M., et al. (2021) 'Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats', Frontiers in Pharmacology, 12. doi: 10.3389/fphar.2021.718147

Tepeš M, Gojković S, Krezić I, Žižek H, Vraneš H, Madžar Z, i sur.. Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats. Frontiers in Pharmacology [Internet]. 13.12.2021. [pristupljeno 15.03.2025.];12. doi: 10.3389/fphar.2021.718147

M. Tepeš, et al., "Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats", Frontiers in Pharmacology, vol. 12, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:063032. [Citirano: 15.03.2025.]

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Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats
AutorMarijan Tepeš
AutorSlaven Gojković
AutorIvan Krezić
AutorHelena Žižek
AutorHrvoje Vraneš
AutorZrinko Madžar
AutorGoran Šantak
AutorLovorka Batelja
AutorMarija Milavić
AutorSunčana Sikirić
AutorIvica Kocman
AutorKarol Šimonji
AutorMariam Samara
AutorMario Knežević
AutorIvan Barišić
AutorEva Lovrić
AutorSanja Štrbe
AutorAntonio Kokot
AutorIvica Sjekavica
AutorToni Kolak
AutorAnita Škrtić
AutorSven Seiwerth
AutorAlenka Boban Blagaić
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA RADIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Radiologija
Sažetak (engleski)
Recently, the stable gastric pentadecapeptide BPC 157 was shown to counteract major vessel occlusion syndromes, i.e., peripheral and/or central occlusion, while activating particular collateral pathways. We induced abdominal compartment syndrome (intra-abdominal pressure in thiopental-anesthetized rats at 25 mmHg (60 min), 30 mmHg (30 min), 40 mmHg (30 min), and 50 mmHg (15 min) and in esketamine-anesthetized rats (25 mmHg for 120 min)) as a... Više model of multiple occlusion syndrome. By improving the function of the venous system with BPC 157, we reversed the chain of harmful events. Rats with intra-abdominal hypertension (grade III, grade IV) received BPC 157 (10 µg or 10 ng/kg sc) or saline (5 ml) after 10 min. BPC 157 administration recovered the azygos vein via the inferior–superior caval vein rescue pathway. Additionally, intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension were reduced, as were the grossly congested stomach and major hemorrhagic lesions, brain swelling, venous and arterial thrombosis, congested inferior caval and superior mesenteric veins, and collapsed azygos vein; thus, the failed collateral pathway was fully recovered. Severe ECG disturbances (i.e., severe bradycardia and ST-elevation until asystole) were also reversed. Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited. In the liver, BPC 157 reduced congestion and severe sinusoid enlargement. In the lung, a normal presentation was observed, with no alveolar membrane focal thickening and no lung congestion or edema, and severe intra-alveolar hemorrhage was absent. Moreover, severe heart congestion, subendocardial infarction, renal hemorrhage, brain edema, hemorrhage, and neural damage were prevented. In conclusion, BPC 157 cured primary abdominal compartment syndrome. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Pharmacology
Brojčani podacivol. 12, 718147
e-ISSN1663-9812
DOIhttps://doi.org/10.3389/fphar.2021.718147
URN:NBNurn:nbn:hr:105:063032
Datum objave publikacije2021-12-13
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fphar.2021.718147/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-28 08:52:44
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