Cervicobrachial syndrome, also known as cervical radiculopathy, is a relatively common neurological and degenerative disorder resulting from nerve root dysfunction, which is often duo to mechanical compression. However, inflammatory cytokines released from damaged intervertebral disks can also result in symptoms. The aim of this review is to present the epidemiology and etiology of the disease, its pathophysiological mechanisms, diagnostic procedures, and differential diagnosis and methods of treating the symptoms of the disease. The incidence of cervical radiculopathy reaches its peak in the fourth and fifth decades of life. The main two pathophysiological mechanisms of the disease include acute intervertbral disk herniation and degenerative cervical spondylosis. Pain is the most common symptom. It can be described as sharp, persistent and burning, localized in the neck, shoulder, arm or fingers, depending on the level of nerve root involvement. Other common symptoms include numbness, muscular weakness, and hyporeflexion. Cervical radiculopathy can often be diagnosed with a thorough history and physical examination, but a magnetic resonance imaging or computed tomography should be used to confirm the diagnosis. In the absence of myelopathy or significant muscle weakness all patients should be treated conservatively for at least 6 weeks. Conservative treatments consist of immobilization, anti-inflammatory medications, physical therapy, and epidural steroid injections. About 90% of patients respond well to conservative therapy. For patients who are persistently symptomatic despite conservative treatment, or those who have a significant functional deficiti surgical treatment is appropriate. Surgical options include anterior cervical decompresson and fusion, cervical disk arthroplasty, and posterior foraminotomy.