Organocatalytic synthesis of α,α–diaryl substituted α–amino acid derivatives by an interrupted three-component Ugi reaction / Danijel Glavač, Ivanka Jerić, Matija Gredičak.
Sažetak
An organocatalytic interrupted three-component Ugi reaction for the synthesis of α,α–diaryl α–amino acid derivatives is described. The transformation proceeds with a range of isocyanides and 3-aryl isoindolinone alcohols using Brønsted acid catalysts to afford products in good to excellent yields. Based on the obtained results, a reaction mechanism is proposed and discussed.
Croatica chemica acta : 92,2(2019) / editor-in-chief Olga Kronja.
