prikaz prve stranice dokumenta Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
  Preuzmi
PDF 580.9 KB
Znanstveni rad - Izvorni znanstveni rad
Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
Frontiers in Genetics, 9 (2018); 296. https://doi.org/10.3389/fgene.2018.00296
Jelenić, Ivan; Selmecki, Anna; Laan, Liedewij; Pavin, Nenad

Citirajte ovaj rad

Jelenić, I., Selmecki, A., Laan, L. i Pavin, N. (2018). Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells. Frontiers in Genetics, 9.. doi: 10.3389/fgene.2018.00296

Jelenić, Ivan, et al. "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells." Frontiers in Genetics, vol. 9, 2018. https://doi.org/10.3389/fgene.2018.00296

Jelenić, Ivan, Anna Selmecki, Liedewij Laan i Nenad Pavin. "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells." Frontiers in Genetics 9 (2018). https://doi.org/10.3389/fgene.2018.00296

Jelenić, I., et al. (2018) 'Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells', Frontiers in Genetics, 9. doi: 10.3389/fgene.2018.00296

Jelenić I, Selmecki A, Laan L, Pavin N. Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells. Frontiers in Genetics [Internet]. 2018. [pristupljeno 19.04.2024.];9. doi: 10.3389/fgene.2018.00296

I. Jelenić, A. Selmecki, L. Laan i N. Pavin, "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells", Frontiers in Genetics, vol. 9, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:901575. [Citirano: 19.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:217:901575
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
AutorIvan Jelenić
AutorAnna Selmecki
AutorLiedewij Laan
AutorNenad Pavin
MBZ: 204800
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Interdisciplinarne prirodne znanosti
Sažetak (engleski)
Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomyces cerevisiae, the rate of chromosome loss in haploid and diploid cells is measured to be one thousand times lower than the rate of loss in isogenic tetraploid cells. Currently it is unknown what constrains the number of chromosomes that can be segregated with high fidelity in an organism. Here we developed a simple mathematical model to study how different rates of chromosome loss in cells with different ploidy can arise from changes in (1) spindle dynamics and (2) a maximum duration of mitotic arrest, after which cells enter anaphase. We apply this model to S. cerevisiae to show that this model can explain the observed rates of chromosome loss in S. cerevisiae cells of different ploidy. Our model describes how small increases in spindle assembly time can result in dramatic differences in the rate of chromosomes loss between cells of increasing ploidy and predicts the maximum duration of mitotic arrest.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Genetics
Brojčani podacivol. 9, 296
p-ISSN1664-8021
DOIhttps://doi.org/10.3389/fgene.2018.00296
URN:NBNurn:nbn:hr:217:901575
Datum objave publikacije2018
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fgene.2018.00296/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomenaCopyright © 2018 Jelenić, Selmecki, Laan and Pavin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Received: 02 March 2018. Accepted: 13 July 2018. Published: 06 August 2018.
Datum i vrijeme pohrane2020-03-01 11:41:16