The question of the meaning of human life, disease, suffering and death following man from the very beginnings of human history. The search for answers to these questions has not abated to this day. Patients diagnosed with a fatal illness and suffering from physical symptoms also face a great psychological burden as they try to find meaning and purpose in the midst of their own suffering. Palliative care aims to alleviate suffering and improve the quality of life of patients and their families who are facing life-limiting illness, terminal illness, or are in the final stages of life. Palliative care involves care for the whole person, combining a scientific approach with humanistic approaches to care. Care is focused on the patient and the family, and the goal of palliative care is to promote quality of life through different stages of the disease. It has been developed to recognize the specific needs of dying patients and their families for both health and other forms of care. Palliative care combines psychological and spiritual forms of care, helping the family in her patient and in her own grief. Palliative care is interdisciplinary in its approach, with an emphasis on the important role of spirituality. Spirituality has always occupied an important place in a person's life because it helps to transcend and make sense of illness and suffering and thus affects the condition of the sick. The aim of this paper is to emphasize the role of spirituality in palliative care and how it helps to cope with one's own transience and to design meaning of the last moments of life.