Hetairoi were collaborators of Alexander the Great and they held military and administrative functions in his service. As he spent almost the entire reign in conflicts, his associates and confidants were primarily commanders, while only few of them were specifically in charge of administration or diplomacy. Their duties grew over time, as did the Macedonian Empire, and thus their power at court and in the army. The paper will therefore describe all the functions held by Alexander's hetairoi, but also single out the most prominent ones among them. It further describes the differences between companions and confidants and how friendships and family ties have influence at court, primarily through opposing clans and different agendas. In addition to the positive influences on Alexander's reign, the paper will also show the negative ones that came from rival ranks, but also from those who grew up near him. The paper will also deal with relationships and conflicts between groups that had different views on the merging of East and West, some of which were loyal to the king despite everything, and at the end the paper will briefly describe what happened to the legacy of Alexander the Great.