Octavians conquering of Siscia in 35. BC., marked the beginning of the Roman rule in the area. During the reign of Vespasian in 71. AD it received the status of a colony, becoming the most important centre in Pannonia in which the governor of the province resided. This paper presents the main cults in Siscia and material that confirms their worship. Even though the material is scarce for such an important city it is visible that life is diverse and rich. Secular inscriptions are mostly raised by consular beneficiaries, but also by local population and even slaves. The majority of inscriptions are dedicated to Jupiter and Juno. Other cults that are presented in this paper are the cult of Jupiter of Heliopolis, a Romanised Semitic deity, the cult of Diana whose material is rarely found in Pannonia, Silvanus and Liber, and the cult of Mithras. A marble head which is a portrait of Septimius Severus and a marble base that mentions Fulvia Plautilla, Caracalla's wife, indicates the existence of an imperial cult during the dynasty of the Severus. Most of the materials are in private collections or have been extracted from Kupa, and these are mostly statues depicting Athena, Mercury, Venus, Fortune, Priapus, Jupiter, Eros, Dionysus and Hercules.