This paper investigates how the process conditions and the type of chitosan affect the morphology of the chitosan microparticles. Two types of chitosan were used – medium and low molecular weight. Tests were conducted in a spray-dryer in order to obtain spherical particle of uniform particle sizes. Solutions of chitosan were prepared at 0.5 % mass concentration. The solutions were dried in the spray-dryer at different flow rates of atomizing air (40 %, 50 % and 60 %) and different temperatures (160 °C and 180 °C). Feed rate was constant for all experiments (20 %). Due to the increased stability of chitosan, some of the solutions were prepared with the addition of the crosslinking agent, sodium tripolyphosphate. SEM micrographs showed the difference in the morphology of the particles. The resulting particles are donut-shaped, mushroom caps and spherical. The largest proportion of spherical particles was observed for the medium molecular weight chitosan dried at 160 °C and with 40 % flow rate of atomizing air. The particle size distribution is ranging from 0.2 to 300 microns, and it expressed as the Sauter mean diameter. Higher values of Sauter diameter may be due to adherences of particles. The results showed that the design of shape of chitosan particles can be accomplished with the proper selection of process conditions.