prikaz prve stranice dokumenta Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
  Preuzmi
PDF 494.24 KB
Znanstveni rad - Izvorni znanstveni rad
Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
Journal of Ginseng Research, 45 (2021), 5; 546-554. https://doi.org/10.1016/j.jgr.2019.11.005
Jovanovski, Elena; Smirčić-Duvnjak, Lea; Komishon, Allison; Au-Yeung, Fei Rodney; Sievenpiper, John L.; Zurbau, Andreea; Jenkins, Alexandra L.; Sung, Mi-Kyung; Josse, Robert; Li, Dandan; Vuksan, Vladimir

Citirajte ovaj rad

Jovanovski, E., Smirčić Duvnjak, L., Komishon, A., Au Yeung, F. R., Sievenpiper, J. L., Zurbau, A. ... Vuksan, V. (2021). Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial. Journal of Ginseng Research, 45. (5), 546-554. doi: 10.1016/j.jgr.2019.11.005

Jovanovski, Elena, et al. "Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial." Journal of Ginseng Research, vol. 45, br. 5, 2021, str. 546-554. https://doi.org/10.1016/j.jgr.2019.11.005

Jovanovski, Elena, Lea Smirčić Duvnjak, Allison Komishon, Fei Rodney Au Yeung, John L. Sievenpiper, Andreea Zurbau, Alexandra L. Jenkins, et al. "Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial." Journal of Ginseng Research 45, br. 5 (2021): 546-554. https://doi.org/10.1016/j.jgr.2019.11.005

Jovanovski, E., et al. (2021) 'Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial', Journal of Ginseng Research, 45(5), str. 546-554. doi: 10.1016/j.jgr.2019.11.005

Jovanovski E, Smirčić Duvnjak L, Komishon A, Au Yeung FR, Sievenpiper JL, Zurbau A, i sur.. Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial. Journal of Ginseng Research [Internet]. 09.2021. [pristupljeno 19.04.2024.];45(5):546-554. doi: 10.1016/j.jgr.2019.11.005

E. Jovanovski, et al., "Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial", Journal of Ginseng Research, vol. 45, br. 5, str. 546-554, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:788104. [Citirano: 19.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:788104
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
AutorElena Jovanovski
AutorLea Smirčić-Duvnjak
AutorAllison Komishon
AutorFei Rodney Au-Yeung
AutorJohn L. Sievenpiper
AutorAndreea Zurbau
AutorAlexandra L. Jenkins
AutorMi-Kyung Sung
AutorRobert Josse
AutorDandan Li
AutorVladimir Vuksan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: Diabetes mellitus and hypertension often occur together, amplifying cardiovascular disease (CVD) risk and emphasizing the need for a multitargeted treatment approach. American ginseng (AG) and Korean Red Ginseng (KRG) species could improve glycemic control via complementary mechanisms. Additionally, a KRG-inherent component, ginsenoside Rg3, may moderate blood pressure (BP). Our objective was to investigate the therapeutic potential of coadministration of Rg3-enriched Korean Red Ginseng (Rg3-KRG) and AG, added to standard of care therapy, in the management of hypertension and cardiometabolic risk factors in type-2 diabetes. ----- Methods: Within a randomized controlled, parallel design of 80 participants with type-2 diabetes (HbA1c: 6.5-8%) and hypertension (systolic BP: 140-160 mmHg or treated), supplementation with either 2.25 g/day of combined Rg3-KRG + AG or wheat-bran control was assessed over a 12-wk intervention period. The primary endpoint was ambulatory 24-h systolic BP. Additional endpoints included further hemodynamic assessment, glycemic control, plasma lipids and safety monitoring. ----- Results: Combined ginseng intervention generated a mean ± SE decrease in primary endpoint of 24-h systolic BP (-3.98 ± 2.0 mmHg, p = 0.04). Additionally, there was a greater reduction in HbA1c (-0.35 ± 0.1% [-3.8 ± 1.1 mmol/mol], p = 0.02), and change in blood lipids: total cholesterol (-0.50 ± 0.2 mmol/l, p = 0.01), non-HDL-C (-0.54 ± 0.2 mmol/l, p = 0.01), triglycerides (-0.40 ± 0.2 mmol/l, p = 0.02) and LDL-C (-0.35 ± 0.2 mmol/l, p = 0.06) at 12 wks, relative to control. No adverse safety outcomes were observed. ----- Conclusion: Coadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Ginseng Research
Brojčani podacivol. 45, br. 5, str. 546-554
p-ISSN1226-8453
e-ISSN2093-4947
DOIhttps://doi.org/10.1016/j.jgr.2019.11.005
URN:NBNurn:nbn:hr:105:788104
Datum objave publikacije2021-09
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S122684531930106X
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-10 10:02:55