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Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
Biomedicines, 10 (2022), 2; 467. https://doi.org/10.3390/biomedicines10020467
Horvatiček, Marina; Perić, Maja; Bečeheli, Ivona; Klasić, Marija; Žutić, Maja; Kesić, Maja; Desoye, Gernot; Nakić Radoš, Sandra; Ivanišević, Marina; Hranilović, Dubravka; Štefulj, Jasminka

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Horvatiček, M., Perić, M., Bečeheli, I., Klasić, M., Žutić, M., Kesić, M. ... Štefulj, J. (2022). Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta. Biomedicines, 10. (2). doi: 10.3390/biomedicines10020467

Horvatiček, Marina, et al. "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta." Biomedicines, vol. 10, br. 2, 2022. https://doi.org/10.3390/biomedicines10020467

Horvatiček, Marina, Maja Perić, Ivona Bečeheli, Marija Klasić, Maja Žutić, Maja Kesić, Gernot Desoye, et al. "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta." Biomedicines 10, br. 2 (2022). https://doi.org/10.3390/biomedicines10020467

Horvatiček, M., et al. (2022) 'Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta', Biomedicines, 10(2). doi: 10.3390/biomedicines10020467

Horvatiček M, Perić M, Bečeheli I, Klasić M, Žutić M, Kesić M, i sur.. Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta. Biomedicines [Internet]. 17.02.2022. [pristupljeno 11.04.2024.];10(2). doi: 10.3390/biomedicines10020467

M. Horvatiček, et al., "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta", Biomedicines, vol. 10, br. 2, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:594778. [Citirano: 11.04.2024.]

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Podaci o radu
Naslov (engleski)Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
AutorMarina Horvatiček
AutorMaja Perić
AutorIvona Bečeheli
AutorMarija Klasić
AutorMaja Žutić
AutorMaja Kesić
AutorGernot Desoye
AutorSandra Nakić Radoš
AutorMarina Ivanišević
AutorDubravka Hranilović
AutorJasminka Štefulj
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA GINEKOLOGIJU I OPSTETRICIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
The serotonin receptor 2A gene (HTR2A) is a strong candidate for the fetal programming of future behavior and metabolism. Maternal obesity and gestational diabetes mellitus (GDM) have been associated with an increased risk of metabolic and psychological problems in offspring. We tested the hypothesis that maternal metabolic status affects methylation of HTR2A in the placenta. The prospective study included 199 pairs of mothers and healthy full-term newborns. Genomic DNA was extracted from feto-placental samples and analyzed for genotypes of two polymorphisms (rs6311, rs6306) and methylation of four cytosine residues (−1665, −1439, −1421, −1224) in the HTR2A promoter region. Placental HTR2A promoter methylation was higher in male than female placentas and depended on both rs6311 and rs6306 genotypes. A higher maternal pre-gestational body mass index (pBMI) and, to a lesser extent, diagnosis of GDM were associated with reduced HTR2A promoter methylation in female but not male placentas. Higher pBMI was associated with reduced methylation both directly and indirectly through increased GDM incidence. Tobacco use during pregnancy was associated with reduced HTR2A promoter methylation in male but not female placentas. The obtained results suggest that HTR2A is a sexually dimorphic epigenetic target of intrauterine exposures. The findings may contribute to a better understanding of the early developmental origins of neurobehavioral and metabolic disorders associated with altered HTR2A function.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 2, 467
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10020467
URN:NBNurn:nbn:hr:105:594778
Datum objave publikacije2022-02-17
ProjektŠifra: IP-2018-01-6547
Naziv (hrvatski): Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina
Kratica: PLANS
Voditelj: Jasminka Štefulj
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2227-9059/10/2/467
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-18 09:20:58