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Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study
American Journal of Otolaryngology, 41 (2020), 3; 102416. https://doi.org/10.1016/j.amjoto.2020.102416
Košec, Andro; Hergešić, Filip; Matovinović, Filip; Rašić, Ivan; Vagić, Davor; Bedeković, Vladimir

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Košec, A., Hergešić, F., Matovinović, F., Rašić, I., Vagić, D. i Bedeković, V. (2020). Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study. American Journal of Otolaryngology, 41. (3). doi: 10.1016/j.amjoto.2020.102416

Košec, Andro, et al. "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study." American Journal of Otolaryngology, vol. 41, br. 3, 2020. https://doi.org/10.1016/j.amjoto.2020.102416

Košec, Andro, Filip Hergešić, Filip Matovinović, Ivan Rašić, Davor Vagić i Vladimir Bedeković. "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study." American Journal of Otolaryngology 41, br. 3 (2020). https://doi.org/10.1016/j.amjoto.2020.102416

Košec, A., et al. (2020) 'Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study', American Journal of Otolaryngology, 41(3). doi: 10.1016/j.amjoto.2020.102416

Košec A, Hergešić F, Matovinović F, Rašić I, Vagić D, Bedeković V. Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study. American Journal of Otolaryngology [Internet]. 06.2020. [pristupljeno 19.04.2024.];41(3). doi: 10.1016/j.amjoto.2020.102416

A. Košec, F. Hergešić, F. Matovinović, I. Rašić, D. Vagić i V. Bedeković, "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study", American Journal of Otolaryngology, vol. 41, br. 3, Lipanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:502921. [Citirano: 19.04.2024.]

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Naslov (engleski)Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study
AutorAndro Košec
AutorFilip Hergešić
AutorFilip Matovinović
AutorIvan Rašić
AutorDavor Vagić
AutorVladimir Bedeković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA OTORINOLARINGOLOGIJU I KIRURGIJU GLAVE I VRATA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Sažetak (engleski)
Objective: There is no clear cut-off value of serum parathyroid hormone (PTH) or calcium in which patients are at risk for hypocalcemia after total thyroidectomy. We evaluated the usefulness of serum calcium and PTH concentration measurements after total thyroidectomy in predicting late-occurring hypocalcemia. ----- Design: A prospective, single-center, non-randomized longitudinal cohort study of 143 patients undergoing thyroidectomy between August 2019 and December 2019 with serum calcium and PTH levels sampled 1 h after surgery and on the first and fifth postoperative day. Hypocalcemia was defined as serum calcium levels < 2.14 mmol/L regardless of clinical symptoms. Normal PTH range was 1.6-6.9 pmol/L. ----- Measurements: The primary outcome measure was presence of hypocalcemia on the first and fifth postoperative day, analyzed by a logistic regression model. The PTH cut-off value for prediction of hypocalcemia was identified using a ROC curve comparing all three time points using the Youden J index. ----- Results: Out of 143 patients, 52 (36.4%) had hypocalcemia on the fifth postoperative day. Advanced age, concomitant neck dissection and serum PTH levels < 2.9 pmol/L 1 h after surgery and on the first postoperative surgery day were associated with a high risk of hypocalcemia on the first and fifth postoperative day and need for higher doses of calcium supplements (P < 0.0001, AUC 0.748, 95% CI 0.669-0.817, with 76.92% sensitivity and 71.43% specificity). ----- Conclusion: Serum PTH level measured immediately postoperatively and on the first postoperative day is a reliable predictor of postoperative hypocalcemia with important clinical implications.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaAmerican Journal of Otolaryngology
Brojčani podacivol. 41, br. 3, 102416
p-ISSN0196-0709
e-ISSN1532-818X
DOIhttps://doi.org/10.1016/j.amjoto.2020.102416
URN:NBNurn:nbn:hr:105:502921
Datum objave publikacije2020-06
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0196070920300879
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-07-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-01-21 12:52:16